Background: The majority of people infected with SARS-CoV-2 fully recovered within a few weeks. However, a considerable number of patients of different ages, still suffer from long-lasting problems similar to the multi-organ damage in its acute phase of infection, or experience symptoms continuously in a longer term after the recovery.Post-COVID-19 syndrome refers to survivors 4 months after initial symptoms onset. It is important to understand the systemic effects of Post-COVID-19 syndrome, its presentations and the need for rehabilitations to restore functional recovery in survivors. Population Discharged COVID-19 survivors for at least 4 months after initial symptom onset. Setting Public health care Funding source None. Innovation/methods Literature search was done on electronic databases (Pubmed, Embase, Cochrane, Medline) on 6 July 2021. The keywords were: Long Covid-19 Syndrome, Post-COVID-19 Syndrome, Rehabilitations. Studies fulfilling the inclusion criteria were selected to evaluate the systemic effects of Post-COVID-19 syndrome, its clinical presentations and rehabilitation approach and efficacy.