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Theme: Advancing Neurological Care: Innovations in Early Detection and Precision Treatment for Nervous System Disorders
Neurology & Neurological Disorders Proceedings
about NEURO Conclave 2025 conference
Harvard Medical School, USA
Clinical Assistant Professor, Geisinger Commonwealth School of Medicine, USA
Keiser University, USA
Northwestern University , USA
Neurology is a field in medicine which deals with the study of the Nervous system and treatment of the respective disorders. The concerned areas of Neurology are the central nervous system (CNS), peripheral nervous system (PNS), brain, blood vessels, and spinal cord. Neurology is concerned to diagnose and treat the disorders of these parts of humans. The nervous system is considered a complex system that regulates body activities. Neurology count on the scientific study of the nervous system, Neuroscience.
A physician who practices Neurology or doctor specialized in Neurology is called Neurologists. They are trained to interpret or investigate and treat the disorders related to the network of nerve cells and fibers or neurological disorders. Neurologists start with a medical history and then with the neurological examination which encompasses the evaluation of cranial nerves, sensation, cognitive function, motor strength, reflexes, coordination, and movement. They treat disorders like:
Neurology is connected to Psychiatry and Oncology. Even there is a very thin line between Neurology and Psychiatry. The discipline of neurology is widening day by day because of the advancements of Neuroscience and other Medical specialties, which is helping to tackle the neurological disorders and other diseases.
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Market Analysis: The global neurology market is expected to increase at a compound annual growth rate (CAGR) of 3.5 percent from $33.3 billion in 2019 to $39.4 billion in 2024. A recent WHO survey suggested that various neurological disorders collectively accounts for more than 12% of global deaths on average, and it is predicted that the number of death occurred due to neurological diseases will rise from 95 million in 2015 to approximately 103 million in 2030. In 2010, the global cost associated with neurological diseases was estimated to be US$ 2.5 trillion, and it is expected to be over US$ 6 trillion in 2030. High impacting elements such as ongoing neuro mapping research, government initiatives based on neuro science, and algorithms used in the neuro science sectors are driving the market growth.
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Neuroscience is to address and research the function and structure of the nerve cells and fibers which comprises to form of the nervous system. It is a multifaceted and rapidly growing field of biology that looks into the function and structure of the brain and nervous system.
Neuroscience is a sphere where we study the combination of psychology and biology to the extent to understand the physical connection, psychological changes and study of neurological conditions with the brain, that how the brain perceives these changes and connections.
The sphere of Neuroscience encompasses cellular and molecular biology, development, evolution, biochemistry, physiology, anatomy and medical specialty of the nervous system, computational neuroscience, behavioral neuroscience, and cognitive neuroscience.
Neuroscience works closely with the field of engineering, linguistics, mathematics, medicine, psychology, physiology, computer science, and chemistry. Neuroscientists are the researchers who specialize in this branch of biology, Neuroscience, which deals with molecular, biochemistry, physiology and anatomy of the nervous system. They do their research by carrying out and framing the experiments to understand the function of the nervous system and its structure, especially associated with behavior and learning.
Neuroscience and its scope has been expanded exponentially, a consequence of new research being done in this field, from molecular and cellular studies of neurons and to do diagnostic imaging and imaging of brain responses to various changes. Neuroscience is contributing a lot to Neurology, Neurosurgery, Psychiatry and other Neuro-related disciplines.
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Market Analysis: The study of the nervous system is linked to neuroscience. Neuroscience is diverse in terms of research fields and study subjects. The global neuroscience market is expected to reach $36.27 billion by 2024, with a compound annual growth rate (CAGR) of 3.49 percent from 2019 to 2024. Several government and healthcare industry efforts are expected to have an impact on overall market growth. The increased prevalence of neurological illnesses is also having an impact on the industry. In 2016, the global neuroscience market was worth USD 28.42 billion, and it is predicted to increase at a CAGR of 3.1 percent over the next five years. High-impact factors such as ongoing brain mapping research and investigation projects, government-led neuroscience efforts, and technological advancements in neuroscience-related tools and algorithms are likely to boost market expansion.
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Neuropsychiatry is an integral part of medicine and science which deals with mental disorders related to the nervous system. Neuropsychiatry is to study neurology and psychiatry in an integrated form. Neuropsychiatry is growing far from other fields of psychiatry and it is also interconnected with behavioral neurology and neuropsychology.
Neuropsychiatry helps the neuroscience field and is helping to give a better understanding of the psychiatry and neurological disorders in order to treat them in a far better way.
Neuropsychiatrists are the physician who has clinical experience and experience in psychiatry with knowledge of neurological disorders. Neuropsychiatrists primarily treat patients suffering from brain malfunctions. Neuropsychiatrists treats these condition with the help of some tools: functional magnetic resonance tomography (fMRI), clinical neurogenetics, magnetic resonance angiography, neuroimaging, electroencephalography, and neural network theory.
Neuropsychiatry addresses these various conditions under it: patients of Parkinson's with delusion and hallucinations, obsessive-compulsive disorder, schizophrenia, and other conditions as well.
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Market Analysis: Psychiatric and neurological illnesses are becoming increasingly prevalent in society, owing to rising prevalence of these disorders in adolescents and children, as well as changing demographics. Neuropsychiatric illnesses are the leading cause of decreased quality of life and decreased ability to perform. Neuropsychiatric illnesses are responsible for more than 42% of years spent with a disability in Europe. During the anticipated period, the Neuropsychiatric Disorders and Treatment Market is expected to develop at a CAGR of 6.2 percent. The global market for neuropsychiatric drugs was valued at US$ 14,448.6 million in 2019, with a compound annual growth rate (CAGR) of 4.2 percent from 2019 to 2030. Neuropsychiatric disorders are the most common among those over 65. Some of the important factors driving the growth of the neuropsychiatric medicines market are the rising prevalence of neuropsychiatric illnesses globally and the rising desire for better treatment.
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The central nervous system or CNS comprises the brain and spinal cord. It is part of our nervous system and it is termed as central because it is a center that receives information, coordinates it and influences the activity of the whole body. It controls our breathing, thoughts, heart rate, emotions, movement, body temperature, the release of some hormones and other parts as well.
The CNS composed of white and gray matter. This can be found in the brain which is encased by the skull. The outer cortex of the brain contains gray matter and white matter in the tract. White matter works as a connector which connects the various location of nerve cell bodies and carries nerve impulses between neuron. White matter consists of myelinated axons. Gray matter is made of neuropil, neuronal cell bodies, glial cells, synapses, and capillaries. The difference between gray matter and white matter is that the latter contains few myelinated axons and numerous cell bodies, while white matter contains few cell bodies and more long-range myelinated axon tracts.
There are various CNS diseases and conditions. CNS infection causes encephalitis and poliomyelitis, neurological disorders like ADHD, autism, Alzheimer's disease, Parkinson's disease, Multiple Sclerosis (MS), and other, genetic disorders as Krabbe's disease and Huntington's disease.
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Market Analysis: By 2025, the global market for CNS therapeutics is anticipated to reach USD 128.9 billion. The market is growing because to the rising frequency of mental illnesses and increased awareness of psychiatric problems. In addition, the global demand for CNS treatments is growing due to the growing geriatric population and the increased prevalence of lifestyle-related CNS illnesses. In 2016, global mental health therapies revenue accounted for 48% of total revenue, and it is predicted to expand at a high rate between 2016 and 2025,by 2020, the global market for central nervous system pharmaceuticals was worth $82 billion. In 2017, the United States was the largest country in the market, accounting for about 30% of total market share, and is expected to grow at a CAGR of 5.9% over the projected period. The industry is primarily driven by advancements in diagnostics, therapeutics, and drug discovery approaches. Furthermore, with the rising frequency of CNS diseases linked to sedentary lifestyles and chronic mental disorders, the number of patients is predicted to rise.
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Pediatric Neurology or Child Neurology covers the abnormalities of CNS, PNS, brain and spinal cord of the children. The disorders related to above in infants and adolescents are considered under this area of Neurology.
Some conditions under Pediatric Neurology or Child Neurology are:
Child neurologists are one who specializes in Child neurology to diagnose and treat various disorders that occurs in infants, children, and adolescents.
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Market Analysis: Pediatric neurology is a specialty of medicine that deals with neurological problems in kids, such as sleeplessness, speech disorders and headaches. The number of children with neurological abnormalities is steadily increasing. Approximately 600 distinct nervous system illnesses have been identified around the world. During the projected period, 2017-2023, the pediatric neurology devices market is expected to increase at a CAGR of 6.3 percent. The worldwide pediatric neurology device market is dominated by North America. Furthermore, market expansion is supported by factors such as widespread adoption of technologically improved medical equipment, increased governmental support for R&D activities, and high spending in neurological care. The market is predicted to rise exponentially by 2030, thanks to the rising prevalence of neurological diseases in youngsters. Another lucrative market for paediatric neurology devices is Europe. The market is growing as a result of a growing focus on the development of advanced diagnostic equipment and increased government assistance for R&D activities. The Asia Pacific region is quickly emerging as another viable market for paediatric neurology products.
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Neurophysiology is defined as the study of physiology and function of the nervous system. It is to study the functional properties of nerves, glia, and neural networks. Neurophysiology is a part of neuroscience and physiology. Electrophysiological or molecular biological tools are often used in Neurophysiology. Some other researchers define neurophysiology as a study of brain cells.
It is related to mathematical neuroscience, neurochemistry, electrophysiology, neuroanatomy, clinical neuroscience, and biophysics. Neurophysiology uses biological techniques for neurophysiological researches.
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Market Analysis: The global neurophysiology devices and equipment market is predicted to increase at a compound annual growth rate (CAGR) of 7.7% from $1.3 billion in 2020 to $1.4 billion in 2021. Geographically, the global neurophysiology market is divided into five regions - North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Companies are resuming operations and adapting to the new normal as they recover from the COVID-19 impact, which had previously resulted in restrictive containment measures such as social distancing, remote working, and the closure of commercial activities, all of which created operational challenges. At a CAGR of 5.7 percent, the market is estimated to reach $1.75 billion in 2025.
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Neuroimmunology is the study of links between neuroscience and immunology both fields of medicine. It deals with relation to the central nervous system or nervous system with immunology. The term Neuroimmunology is coined in the 1960s. In various Neurological disorders, neuroinflammation and neuroimmune activation have played a major role in understanding the etiology of these disorders.
Neuroimmunologists are the individuals who are supposed to understand these two complex disciplines and draw various conclusions to find the exact causes of the change happening during various neurological disorders, neurological disease, or neurological injury. This research area is rapidly developing and providing us the basic and complex both information to advance the researches of Neurology and Neuroscience to treat neurological disorders in a better way to save many lives.
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Neuropathology, being an integral part of anatomic pathology, is to study the nervous system diseases. This study can be in smaller surgical biopsies or can be studied as whole-body autopsies. Neuropathology has been involved in and playing a key role in characterizing the pathogenesis of neurological disorders.
Neuropathology has played a key role in providing major insights into the pathophysiology of Multiple Sclerosis and neuropathology of neurodegenerative disorders in an adult include nonspecific and disease-specific changes.
Neuropathologists are the physician having specialization in autonomic pathology but they have undergone training of neuropathology for an additional two years. Neuropathologists can handle autonomic pathology, autonomic pathology testing on nervous system tissues as well as neurological or neuromuscular pathology.
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Market Analysis: The disease of nerves that causes pain and numbness in the limbs is known as neuropathology, and it is gaining popularity in this industry. The global neuropathology market is growing due to an increase in the incidence of musculoskeletal diseases and technical developments in medical diagnostic instruments. During the forecast period 2017-2023, the Neuropathology Market is expected to develop at a CAGR of around 6%. By 2027, the Neurology Devices Market will be worth $ 21.02 billion, with a 10.2% compound annual growth rate. The escalating incidence of neurological illnesses, substantial investments by private companies in neurology equipment, increased R&D in the field of neurotherapy, and the ageing population are all driving the market forward.
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Neurodegenerative disease is the group of condition or disease which mainly affect the neurons of the brain. The neurons are the building block of the brain and spinal cords or nervous system. Neurons are irreplaceable as they cannot replicate or reproduce after suffering damage which eventually death of the neuron.
Neurodegeneration is a loss in the structure and function of neurons.
Aging is the main cause of neurodegenerative disease. Neurodegenerative disease progress with age as the neurons become less functional. Oxidative stress, mitochondrial DNA mutation, and other factors lead a human body to age. Genetics, protein folding, DNA damage, mitochondrial dysfunction, programmed cell death, protein degradation pathways and other leads to the mechanism of neurodegenerative diseases. The cure of neurodegenerative disease is not yet discovered as causes of most of the cases are still a mystery.
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Market Analysis: Neurodegenerative diseases refer to a group of brain disorders that lead to progressive degeneration of the structure and function of neurons in the central nervous system (CNS) or peripheral nervous system (PNS). The global neurodegenerative disease treatment market grew at a CAGR of around 8% during 2015-2020.
The Neurodegenerative Disease market was worth around USD 39.24 billion in 2020, and is predicted to reach USD 44.90 billion in 2026, with a CAGR of 2.30 percent.The global neurodegenerative disorder therapeutics market is predicted to increase at a compound annual growth rate (CAGR) of 7.9% from $14.08 billion in 2020 to $15.19 billion in 2021. The growth is mainly due to the companies resuming their operations and adapting to the new normal while recovering from the COVID-19 impact, which had earlier led to restrictive containment measures involving social distancing, remote working, and the closure of commercial activities that resulted in operational challenges. The market is expected to reach $20.15 billion in 2025 at a CAGR of 7%.
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Neurological disorders are defined as disorders that affect the brain, spine and nerves throughout the human body. It is either associated with CNS or PNS or both. Structural, biochemical or electrical abnormalities can cause a wide range of neurological problems which eventually might lead to different types of mild to severe neurological disorders.
Neurological disorders have different causes and symptoms. Most of them start or emerge during the early stage of life or maybe diagnosed at birth. The symptoms of Neurological disorders vary in each disorder. Congenital causes, gene abnormalities, metabolic disorders, prenatal causes, nutritional deficiencies, complications during childbirth, acquired causes, immune disorders, traumatic brain injury, and toxins are some of the causes of Neurological disorders.
Some neurological disorders are:
Parkinson's disease
Amyotrophic lateral sclerosis or ALS
Brain tumors
Epilepsy
Stroke
Peripheral Neuropathy
Key treatment methods of Neurological disorders:
Neuroimaging techniques to diagnose
Brain mapping
Cognitive therapy treatment
Pain management
Physiotherapy
Deep brain stimulation
There are various other methods to treat these lifelong neurological disorders.
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Market Analysis: The global neurology market is expected to increase at a compound annual growth rate (CAGR) of 3.5 percent from $33.3 billion in 2019 to $39.4 billion in 2024. Anticholinergic, antiepileptic, antipsychotic, hypnotic & sedative, analgesics, antihypertensive, anticoagulants, and others are the drug types that make up the global neurological diseases treatment market. According to a study, an estimated 5.4 million Americans suffer from Alzheimer's disease, and someone in the United States acquires the condition every 68 seconds.Due to key driving factors such as increasing prevalence of neurological disorders, developing healthcare infrastructure, rising awareness associated with neurological diseases, which is fueling the rate of diagnosis, and mounting accessibility of modern treatments in developing countries such as China, India, and Indonesia, Asia Pacific was identified as the fastest growing region between 2021 and 2029. According to the report, the global market for neurological disease pharmaceuticals was worth US$ 70 billion in 2018 and is expected to grow at a CAGR of 5% from 2019 to 2027.
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The group of condition which changes or alters or hinders the normal pattern of sleep comes under Sleep disorders. This disorder can affect our overall health and make us prone to stress and anxiety. There are various causes for sleep disorders like medical conditions (heart disease, lung disease, and nerve disorder), mental disorder, genetics, not enough sleep, stress, anxiety, irregular sleep, medicines, and aging. Sometimes the reason for a sleep disorder is unknown as these disorders are very complex.
Depression, lack of concentration, fatigue in the daytime, difficulty in sleeping, and anxiety are the symptoms of sleep disorders. Some types of sleep disorders are insomnia, parasomnias, sleep apnea, and narcolepsy. For the diagnosis of sleep disorders, the doctor goes through the patient's medical history and some tests. These tests include genetic blood testing, electroencephalogram, polysomnography, breathing rate, and eye movements. Sleep disorders can be treated by good sleeping habits, medical treatments, by changing lifestyle, and relaxation techniques.
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Market Analysis: Sleep disturbance, also known as somnipathy, is a medical illness in which the sleep cycle is disrupted. It can also be defined as a group of disorders that have a regular impact on sleep patterns. Sleep disturbances can be caused by a variety of circumstances, including health problems and high stress levels. During the forecast period, the worldwide sleep disorders treatment market is expected to grow at a CAGR of roughly 7.1 percent. Sleep disorders are becoming more common around the world, and rising stress levels, a growing geriatric population, and increased understanding about various treatment choices for this illness are all likely to drive the industry forward.North America currently dominates the market for sleep disorders, and it is anticipated to do so for a few more years. The market is expected to be driven by rising demand for sleep disorder treatment in the United States and Canada, rising prevalence of sleep disorders, more awareness, and high healthcare spending. From USD 7,852.54 million in 2020 to USD 14,732.08 million in 2028, the global sleep disorder treatment market is predicted to increase at an annual rate of 8.4% from 2021 to 2028.
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Movement disorders, a neurological condition, in which an abnormal increase or reduction in movement is observed, which is voluntary or involuntary. Movement disorder is divided into two categories:
Hyperkinetic movement disorders: It is the involuntary movement which hinders the normal movement of motor activity of the body. It refers to repetitive movement or dyskinesia.
Hypokinetic movement disorders: It is the slow motion of the body parts or motor activity. As it refers to hypokinesia - reduced amplitude of movement, akinesia – lack of movement, rigidity, and bradykinesia – slow movement.
Some movement disorders are:
Treatment of these disorders depends on movement disorders.
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Market Analysis: Neurological diseases and syndromes that impact the ability to create and govern movement are known as motor system disorders or Movement Disorders. This condition mostly affects the brain, spinal cord, and nerves throughout the body, resulting in cerebrovascular disorders, adult degenerative diseases, and other complications. The primary growth drivers of the movement disorder market are the recent development of efficient and advanced technology, rising prevalence of neurodegenerative disorders, patent expiration of several bestseller medications, and the appearance of new technologies globally.The increasing cost of research and development, on the other hand, is a major barrier for the worldwide Musculoskeletal Diseases market. From 2021 to 2030, the global market for motor system disorders is expected to grow at a CAGR of 9.80%. Because of the high frequency of the illness, increased awareness among the patient population, and technological improvements, North America held a considerable market position in the worldwide neurological movement disorders market in 2020.
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Parkinson's disease, a movement disorder, is a progressive neurological disorder, the condition progresses over time. In Parkinson's disease, the cells which are responsible to secrete dopamine begin to die. Dopamine is responsible for the smooth functioning of the muscle of the body. Dopamine is secreted by the cells of the substantia nigra, a part of the brain.
Parkinson's disease symptoms including the change in voice, slurry voice, tremor, slow movements, anosmia, balancing problem, stiffness of arms, legs and trunks, facial expression start to change, and loss of sense of smell. These symptoms are due to a decrease in levels of dopamine leading to abnormal brain activity.
The cause which leads to low levels of dopamine is not yet clear. But there are many factors which lead to Parkinson's disease, maybe genetic factors and environmental causes. As there is no specific test to diagnose Parkinson's disease, a dopamine transporter test scan can be used.
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Market Analysis: In the United States, it is the second most common neurodegenerative disorder.The global Parkinson's disease treatment market is predicted to grow at a CAGR of 6.1 percent from USD 4.24 billion in 2017 to USD 5.69 billion in 2022. The market is being driven by the growing ageing population and government financing for Parkinson's disease research. The Parkinson's disease (PD) market is predicted to develop significantly in the next seven years, with a 12.6 percent compound annual growth rate starting in 2019. (CAGR). Parkinson's disease is expected to affect 1.2 million people in the United States by 2030, according to the National Institute of Health.
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Neuromuscular disease encompasses various disease and disorders which affects the nerves that control muscle function and neuromuscular system. Neuromuscular disorders can generate difficulties with the nerves carrying information back to the brain, nerves that control voluntary muscles, and transmission between nerve and muscles. These disorders can make the muscles weak and may lose functioning as well.
Some signs and symptoms of neurological disorders or neurological disease are muscle loss, muscle weakness, double vision, trouble breathing and swallowing, numbness, balancing problem, and movement issues. Signs and symptoms for some of the neurological disorders can be visible in the infant stage as well. In general, there is no cure for these disorders. But prevention, prognosis, and management of these diseases vary according to the severity and types of these disorders.
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Market Analysis: The global neuromuscular disorders therapeutics market is expected to increase by USD 6.05 billion from 2019 to 2023, with a compound annual growth rate (CAGR) of over 14% from 2021 to 2023. A number of innovative therapies for the treatment of diverse indications have been approved in the neuromuscular disorders therapeutics market. This is primarily owing to advanced study on severely morbid and progressive indications.One of the major neuromuscular illnesses for which treatment approvals have been granted is spinal muscular atrophy. During the period 2019-2023, the global neuromuscular disease treatments market would rise by USD 6.05 billion.
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Speech is the process of producing specific sounds that convey meaning to the listener. A speech disorder refers to the conditions in which an individual has problems in creating or forming the speech sounds needed to communicate with others. The act of speaking requires the specific coordination of multiple body parts, including the brain, neck, chest, and abdomen.
Speech disorders can affects both adults and children. Many children will experience a temporary delay in speech and language development. Most will eventually catch up. Others will continue to have difficulty with communication development.
Causes of speech disorders include:
Brain damage due to a stroke or head injury
Muscle weakness
Damaged vocal cords
A degenerative diseases
Dementia
Cancer that affects the mouth or throat
Autism
Down syndrome
Hearing loss
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Market Analysis: The speech disorder market is predicted to increase as a result of key driving factors such as rising neurological disorders, rising birth rates of speech abnormalities, and rising speech disorder services. Growing technology advancements are predicted to provide new approaches, goods, and services to treat speech impairments, giving the market room to expand. For the projection period of 2021-2028, the speech impairment market would grow at a CAGR of roughly 3.81 percent. The rising prevalence of brain injuries, tumours, and Parkinson's diseases, as well as increased focus on medical device research and development and adoption of advanced healthcare technologies, as well as rising expenditure on healthcare infrastructure development, particularly in developing economies, are all contributing to the growth of the speech impairment market. The market for speech disorders is divided into three categories: category, patient type, and service provider. The market is divided into apraxia, cluttering, dysarthria, neurological speech problem, and others based on kind.
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The damage of the protective covering (myelin sheath) that surrounds nerve fibers in brain, optic nerves and spinal cord leads to development of demyelinating disorders. The damaged myelin sheath makes the nerve impulses slow or even stop, causing neurological problems. Demyelination causes neurological deficits, such as vision changes, weakness, altered sensation, and behavioral or cognitive problems. Demyelination can occur at any age.
Symptoms of demyelinating diseases include
Loss of vision
Numbness or tingling of upper or lower limbs
Weakness of the arms or legs
Poor coordination/gait problem
Trouble walking
Difficulty in swallowing
Slurred speech
Deceased bowel or bladder control
Impaired memory
Mood or behavioral changes
Genetic mutations, infectious agents, autoimmune reactions, Vitamin B12 deficiency and other unknown factors results in dysmyelination.
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Market Analysis: In the forecast period of 2020 to 2027, the global market for demyelinating disorders treatments is expected to increase. The myelin sheath, a protective layer that surrounds nerve fibres in the brain, optic nerves, and spinal cord, is damaged in demyelinating illnesses. The market for demyelinating disorders therapies is divided into immunomodulators, immunosuppressants, interferons, and others based on medication class. The market for demyelinating disorders therapies is divided into two segments: oral and parenteral. he demyelinating disorders therapeutics market is divided into hospitals, homecare, specialty clinics, and others based on end users. The market for demyelinating disorders therapeutics has been divided into three categories based on distribution channels: hospital pharmacy, online pharmacy, and retail pharmacy.
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Cerebrovascular disorder refers to the condition in which blood flow in the brain is blocked or limited for temporarily or permanently. It includes all disorders in which an area of the brain is affected by ischemia or bleeding. Restrictions in blood flow may occur from vessel narrowing clot formation, blockage or hemorrhage. Cerebrovascular disease can develop from a variety of causes such as atherosclerosis, embolic arterial blood clot, cerebral venous thrombosis, blood vessel damage, and hypertension. There are also many less common causes of cerebrovascular disease, including those that are congenital or idiopathic and include CADASIL, aneurysms, amyloid angiopathy, arteriovenous malformations, fistulas, and arterial dissections.
Common symptoms include:
A severe and sudden headache
Hemiplegia
Hemiparesis
Confusion
Slurred speech
Vision loss on one side
loss of balance
Loss of conciousness
Sub-track
Market Analysis: During the forecast period, the worldwide cerebrovascular disease treatment market is expected to develop at a significant CAGR of 5.9%. The advancement of technology and the rising occurrence of strokes are two main factors driving the growth of the cerebrovascular disease treatment market. The cerebrovascular disorders market may be divided into four key regions based on geography: North America, Europe, Asia Pacific, and the Rest of the World (RoW). North America leads the global market for cerebrovascular illness, followed by Europe. During the projected period 2021-2027, the global "Cerebrovascular Disease Market" is expected to develop at a stable rate.
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Immune system protects the human body from disease and infection. However incase of autoimmune disease, immune system attacks healthy cells in the body by mistake. There are many systemic disorders with possible involvement of the nervous system with presumed inflammatory and autoimmune pathomechanisms. Abnormal inflammatory response is closely associated with in autoimmune diseases. These inflammations cause impaired functioning, resulting in neurological or psychiatric symptoms. Multiple sclerosis, myasthenia gravis, and Guillain-Barré syndrome are some of the most well known neurological diseases induced by abnormal autoimmunity.
The exact cause of immune-system misfire is unknown although some people are more likely to get an autoimmune disease than others. Certain autoimmune diseases, like multiple sclerosis and lupus is hereditary. Not every family member will necessarily have the disease, but they inherit a susceptibility to an autoimmune condition. As the incidence of autoimmune diseases is rising, researchers are also investigating environmental risk factors like infections and exposure to chemicals. Autoimmune disorders of the nervous system may affects both CNS and PNS, including the brain, spinal cord, peripheral nerves, neuromuscular junction and skeletal muscle.
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Market Analysis: The global autoimmune disease therapeutics market was worth $109,833 million in 2017, and is expected to grow at a CAGR of 4.2 percent from 2018 to 2025, to reach $153,320 million. An autoimmune illness is a condition in which the immune system attacks and destroys its own body tissue. During the forecast period, the autoimmune disease diagnostics market is expected to grow at a CAGR of roughly 8.3%. Rising global awareness of autoimmune disorders as a result of research, education, support, and advocacy activities is a major reason driving up the use of autoimmune disease diagnostics. The global autoimmune disease diagnosis market is estimated to increase at a CAGR of 8.9% from USD 4.1 billion in 2020 to USD 6.3 billion in 2025. The global autoimmune disease therapeutics market was worth $109,833 million in 2017, and is expected to grow at a CAGR of 4.2 percent from 2018 to 2025, to reach $153,320 million. From 2018 to 2025, the global autoimmune disease treatments market is estimated to increase at a CAGR of 4.2 percent, from about $109.83 billion in 2017 to $153.32 billion in 2025.
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Neuropathy, this term indicates damage or dysfunction of one or more nerves that typically results in numbness, tingling, muscle weakness and pain in the affected area. Neuropathy is mostly called as peripheral neuropathy. Peripheral nervous system is the network of nerves outside the brain and spinal cord. Neuropathy results when nerve cells, called neurons, are damaged or destroyed, as it disrupts the way the neurons communicate with each other and with the brain. Neuropathy can either affect one nerve (mononeuropathy) or nerve type, a combination of nerves in a limited area (multifocal neuropathy) or many peripheral nerves throughout the body (polyneuropathy).The peripheral nervous system is made up of three types of nerves, sensory nerves carry messages from the five senses (sight, hearing, smell, taste, touch) through the spinal cord to the brain. On the other hand motor nerves travel in the opposite direction of sensory nerves. They carry messages from brain to muscles. Motor nerves are responsible for movement coordination. Autonomic nerves are responsible for body functions by direct control, such as breathing, digestion, heart rate, blood pressure, sweating, bladder control and sexual arousal.
Health conditions that can cause peripheral neuropathy include
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Market Analysis: According to the World Health Organization (WHO), it was estimated that there would be 285 million diabetics by 2010 in the world. This estimate is projected to increase by 65% to become 438 million in the year 2030. Thus, rising prevalence of diabetes mellitus is expected to increase the population of patients suffering from peripheral neuropathy. The global diabetic neuropathy market size was valued at USD 3.61 billion in 2018 and is projected to reach USD 7.12 billion by 2026, exhibiting a CAGR of 8.9% during the forecast period. By 2030, all of these cases are predicted to rise. The Diabetic Neuropathy Market is expected to grow at an annual rate of 8.9% till 2026. The market was valued USD 3.61 billion in 2018 and is expected to grow at an annual rate of 8.9% from 2019 to 2026. The global peripheral neuropathy market was worth US$ 1,470.9 million in 2016, and is predicted to grow at a CAGR of 3.2 percent from 2017 to 2025, reaching US$ 1,998.8 million.
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Cognitive neuroscience investigates the cognitive function that emerges from the physiochemical activity of neurons in the brain. It is associated with the study of the biological processes and various aspects that trigger cognition, with an explicit focus on the neural connections in the brain which are involved with mental processes. This is definitely at the intersection of psychology and neuroscience. Research in this field mostly focuses on the neural mechanisms of perception, selective attention, memory, language, emotion and consciousness for the better understanding the patients with brain damage and also to understand how the healthy brain changes with aging.
Market Analysis: During the forecast period, the Neuroscience market is expected to increase at a CAGR of roughly 4.1 percent. Rising illness burden of brain-related disorders, innovation in the field of neuroscience and neuro-technology, and increasing R&D spending and government support are some of the factors driving market expansion.
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The term motor disorders refer to a group of disorders caused by the malfunctions or damage of the nervous system which results in involuntary or uncontrollable movements or actions of the body. These disorders manifest lack of movement coordination or an excess of involuntary movement.
Symptoms of motor disorders include
• Tremors
• Gait problems
• Spasms and dystonia
• Spasticity
• Cognitive and behavioral problems
• Swallowing and speaking difficulties
Pathological changes in certain areas of the brain are the foremost causes of most motor disorders. Besides that it could also cause due to some chronic diseases such as overactive thyroid, Iron deficiency, Neurodegenerative conditions etc. Some of the inherited genetic defects also lead to onset of motor disorders.
Sub-track
• Motor neuron disease (MND)
• Ataxia
• Dystonia
• Essential Tremor
• Huntington's Disease
• Multiple System Atrophy (MSA)
• Progressive Supranuclear Palsy (PSP)
• Rett Syndrome
• Spasticity
• Tourette Syndrome
• Wilson's Disease
• Physiotherapy
• Occupational therapy
• Deep brain stimulation
Market Analysis: Neurological diseases and syndromes that impact the ability to create and govern movement are known as motor system disorders or Movement Disorders. This condition mostly affects the brain, spinal cord, and nerves throughout the body, resulting in cerebrovascular disorders, adult degenerative diseases, and other complications. The primary growth drivers of the movement disorder market are the recent development of efficient and advanced technology, rising prevalence of neurodegenerative disorders, patent expiration of several bestseller medications, and the appearance of new technologies globally.The increasing cost of research and development, on the other hand, is a major barrier for the worldwide Musculoskeletal Diseases market. From 2021 to 2030, the global market for motor system disorders is expected to grow at a CAGR of 9.80%. Because of the high frequency of the illness, increased awareness among the patient population, and technological improvements, North America held a considerable market position in the worldwide neurological movement disorders market in 2020.
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The impact of neurological damage and disease on behaviour, memory, and cognition is studied in behavioural neurology, a specialisation of neurology. Neuropsychiatry and neuropsychology are two areas related to behavioural neurology. Three types of clinical syndromes are covered by behavioural neurology: 1) brain diseases impacting cognition and behaviour, both diffuse and multifocal 2) Neurobehavioral syndromes linked with localised brain lesions, and 3) neurological illnesses with neuropsychiatric symptoms. These syndromic categories can be split into neurodegenerative) and systemic toxic-metabolic brain illnesses based on their aetiology. A behavioural neurologist investigates and treats cognitive and behavioural problems caused by a brain illness or damage.
Sub-tracks:
• Cognitive Rehabilitation
• Geriatric Behavioral Neurology
• Childhood-Onset Neurobehavioral Disorders
• Neuropsychiatry
• Autoimmune and inflammatory encephalopathies
• Meningoencephalopathy
• Prion disorders
Market Analysis:The global market for behavioural neurology is predicted to expand at a compound annual growth rate (CAGR) of 3.5 percent from $33.3 billion in 2019 to $39.4 billion in 2024. The availability of a disproportionately high number of products and services in behaviour analysis utilising various animal models is projected to fuel this segment's growth. Because of its applicability in chronic brain dysfunction analysis utilising static markers, neural activity implants are projected to account for significant increase in the segment of stereotaxic procedures.
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Computational neuroscience is a branch of neuroscience that investigates brain function using mathematical techniques and theories. It is an interdisciplinary discipline that focuses on the construction, simulation, and analysis of multi-scale models and theories of brain function, ranging from molecules to cells and networks, and finally to cognition and behaviour. In order to understand how the nervous system processes information, it can also include various methodologies from electrical engineering, computer science, and physics. Computational neuroscience's ultimate goal is to explain how electrical and chemical signals in the brain are used to represent and interpret information. It covers biophysical computation mechanisms in neurons, computer simulations of neural circuits, and learning models.The study of brain dynamics can be separated further into two streams. One school of thought, epitomised by Hodgkin and Huxley's work, focuses on the biophysics of single neurons. The other is concerned with the dynamics of networks, namely phenomena that arise from the interconnections of neurons. As a result, there are three subspecialties in computational neuroscience: neural coding, neurobiophysics, and neural networks.
Sub-tracks:
• Computational Vision
• Neural Circuits and Neural Coding
• Neuro AI
• Statistical Analysis of Neural Data
• Neural Models and Theory
• Neuromorphic engineering, and Robotics
• Brain–computer Interfaces
• Neuroinformatics
Market Analysis : Because of the high market prices of instruments used in neuro-analytical investigations, the instrumentation for neuroscience market in technological components accounted for the greatest market share in terms of revenue. Because of developments in the creation of effective data tracing and manipulation algorithms, data analysis and software tools are expected to increase significantly throughout the projection period. Over the next five years, the Neuroscience Market will increase at a CAGR of 4.1 percent. Computational neuroscience is one of neuroscience's fastest-growing subfields. To make sense of the reams of data produced by newer large-scale recording technologies, new analysis and modelling tools are urgently needed.
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Neurogenetics is a new field of science that aims to better understand the causes of brain and nerve illnesses by utilising current developments in genome sequencing. A branch of research aimed at better understanding the genetic roots of mental illnesses. The role of genetics in the development and function of the nervous system is studied in neurogenetics. It treats neural traits as phenotypes and is based on the observation that individuals' neurological systems, even within the same species, are not always identical. As the name implies, it incorporates elements from both neuroscience and genetics research, with a special focus on how an organism's genetic code influences its manifested features. Neurogenetics is used to investigate neurological illnesses, behaviour, and personality. Neurogenetics is also assisting in the advancement of the individualised clinical care paradigm. Physicians can build highly personalised treatment programmes for each patient based on a thorough understanding of their genetic profile and medical history.
Sub-tracks:
• Autism spectrum disorder
• Brain malformations
• Developmental delay
• Intellectual and cognitive disability
• Neurologic disorders in children
• Pediatric Genetic Counseling.
• Molecular diagnosis and therapeutic approaches
• Gentetic testing and screening
Market Analysis : According to Persistence Market Research's newest research, the neurogenetic testing market is expected to develop at a CAGR of 7% from 2021 to 2031. Neurogenetic disorder is caused by a mutation in one or more genes that impact the neurological system. Dementia, genetic neuropathy, Parkinson's disease, epilepsy, and other neurological illnesses are examples. Advancements in DNA sequencing technology and increased research in the life science area are driving the Neurogenetic Testing market. These techniques provide a precise therapy plan for the disease. The increasing frequency of neurological illnesses, public awareness of genetic screening, availability of current diagnostic technologies, and increased life science R&D are the main drivers of demand for neurogenetic testing. DNA sequencing is undergoing a number of technological breakthroughs.
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Child psychology is a subfield of psychology, concerned with how a child's psychological development changes from conception and before, through infancy and childhood, to adolescence and adulthood.
Numerous ailments throughout life cause mental issues because, as we know, psychological well-being is the absence of mental illness. Few juveniles and children experience mental illness. If left untreated, these conditions have an effect on the healing process.
Some people have even questioned if mental illness is real. We'll discuss the most recent concerns with children's mental health as well as research on emotional wellness screening and assessment methods, how the environment affects children, the role of parents in their development, and the psychological characteristics of young children.
The significance of child psychology:
• To better comprehend a child
• To understand the psychologically based issue
• To effectively and meaningfully provide dental treatments
• To develop effective communication between the parent and the child
• To emphasise the value of basic and preventive care to the kid and parents
Child psychology focuses on five key topics:
• Development might have a significant impact on that in another. For instance, writing words involves both fine-motor coordination and linguistic processing abilities. Research has proven that development adheres to specific patterns or principles in addition to its various fields of application. How we care for, treat, and educate children today has been greatly impacted by our understanding of these concepts.
Three areas of Child Development include:
1. Physical development
2. Cognitive or intellectual development
3. Social and emotional development
• Milestones: Psychologists frequently use developmental milestones to assess a child's development in a number of crucial areas. They serve as developmental checkpoints to determine what the typical child can perform at a certain age. Understanding the developmental milestones for various ages benefits child psychologists in understanding typical child development and helps spot potential issues with delayed development.
Four Major Groups of Developmental Milestones:
1. Physical milestones
2. Cognitive or mental milestones
3. Social and emotional milestones
4. Communication and language milestones
• Behaviour
• Emotions
• Socialisation
Market Analysis: According to the WHO, 10-20% of children and adolescents worldwide experience mental health issues. The majority of psychiatric illnesses begin between the ages of 14 and 20 on average. Major obstacles for kids with mental illnesses include stigma, exclusion, and prejudice, as well as limited access to educational and medical services. The Care Quality Commission discovered that between 2019–2023, 50% of the wards were almost full with a 90% occupancy rate, and 16% of the units visited by their officers were beyond capacity. Only 65% of those who have psychiatric problems really obtain treatment, according to observations.
The cost of providing services has increased along with the number of patients, and it is now predicted to be £1.6 trillion more expensive globally than the combined costs of heart disease, cancer, diabetes, chronic respiratory illness, and cancer. Only 5.5% of the overall UK health research budget, or £115 million, is currently allocated to studying the mental health of society's most vulnerable members.
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Social cognitive neuroscience is the study of the neural mechanisms in the human brain that enable individuals to effectively comprehend themselves, understand others, and interact with others.
Social cognitive neuroscience is an emerging interdisciplinary field of study that aims to comprehend phenomena in terms of interactions between three levels of analysis:
• The social level, which is interested in the motivational,
• Social factors that affect behaviour and experience
• The cognitive level, which is interested in the information-processing mechanisms that give rise to social-level phenomena; and the neural level, which is interested in the brain mechanisms that instantiate cognitive-level processes.
Social cognitive neuroscience investigates social events and processes using cognitive neuroscience research techniques such as neuroimaging and neuropsychology.
According to the social cognitive theory, goals, outcome expectations, self-efficacy, and sociostructural variables all have a role in determining behaviour.
Cognitive neuroscience techniques include:
• Functional neuroimaging
• Electrophysiology
• Cognitive genomics
• Behavioral genetics
As a result, there are no effective treatments for either the illness that causes neurocognitive dysfunction or the problem itself. Although many drugs, including antidepressants and antipsychotic alternatives alert that address blackout and other activity symptoms, could help treat the condition. The symptoms and their effects are only suppressed; nonetheless, these are not the right answers. Targeting particular brain regions will be made easier with the use of recently created mental exercises like "computerised brain coaching programmes." Memory loss is not diagnosed in diseases like dementia if an underlying condition like an infection is to blame. Many methods, as opposed to just medicine, can be used to identify most knowledge-related ailments if they are delicate.
Market Analysis: The Neuroscience market is anticipated to grow at a CAGR of about 4.1 percent during the forecast period. Some of the reasons driving market expansion include the rising prevalence of brain-related illnesses, advancements in neuroscience and neurotechnology, rising R&D spending, and government assistance. By 2031, the market for brain imaging technologies will be worth $20,209.2 million.
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Neurophysics or neurobiophysics is the field of biophysics focuses on the development and application of physical strategies to learn more about the neurological system.
Neurophysics is an interdisciplinary field of study that integrates different branches of neuroscience with physics to better understand brain processes. Other physical measurements like EEG, which are primarily used to study electrical, mechanical, or fluidic properties, are combined with theoretical and computational methods in the methodologies used.
Neurophysics Therapy: The very advanced exercise-based therapeutic procedure known as neurophysics therapy. This method successfully treats a large number of disorders and has a high success rate.
The following is a list of some serious conditions that can be treated with neurophysics therapy.
• Arthritis
• Rehabilitation
• Migraine
• Chronic pain
• Degenerative disorders
• Depression
• Epilepsy
• Parkinson’s disease
• Hereditary spastic paraplegia
Additionally, practising neurophysics helps us stay healthy and perform better in daily life since it teaches us a technique for distributing stress throughout the body evenly and preventing it from being isolated.
Market Analysis: The market for neuroscience is anticipated to increase at a compound annual growth rate (CAGR) of 3.49 percent from 2019 to 2024, reaching $36.27 billion. On average market growth, a number of government and healthcare sector initiatives are anticipated to have an impact. The sector is also being impacted by the rising incidence of neurological diseases. The market for neuroscience products and services was valued at USD 28.42 billion in 2016, and it is anticipated to grow at a CAGR of 3.1 percent over the following five years.
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Nano-neurology is an interdisciplinary field that studies the relationship between nanotechnology and neuroscience. It entails studying and manipulating the nervous system at the molecular and cellular levels using nanoscale materials, equipment, and techniques. The basic goals of nano-neuroscience are to increase our understanding of the structure and function of the nervous system, develop new diagnostic tools, and discover novel therapeutics for neurological illnesses.
Here are some of the most important aspects of nano-neuroscience:
Imaging and Sensing: Nanotechnology allows for the development of high-resolution imaging techniques capable of displaying neural architecture and activity in unprecedented detail. This covers imaging techniques such as super-resolution microscopy and nanoparticle- based contrast agents.
Drug Delivery: Drugs or therapeutic compounds can be carried and delivered directly to specific parts of the nervous system using nanoparticles. This method of medicine delivery reduces negative effects while increasing therapeutic efficacy.
Neural Interfaces: Highly sensitive neural interfaces can be created using nano-sized materials and electrodes. These interfaces can precisely record brain impulses or trigger neurons for therapeutic purposes. They are critical for developing brain-computer interfaces (BCIs) and neuroprosthetic devices.
Regenerative Medicine: Nano-neuroscience contributes to tissue engineering and regenerative medicine by providing scaffolds and materials that encourage neural tissue growth and repair. This is critical in the treatment of disorders such as spinal cord injuries and neurodegenerative diseases.
Diagnostic Tools: Nanoscale biosensors and biomarkers can be utilized to detect and monitor neurological illnesses early on. They are capable of detecting specific proteins or compounds linked to neurodegenerative illnesses, offering crucial diagnostic information.
Neuropharmacology: Nanotechnology can help in medication development in neuropharmacology by making it easier to create nanoparticles that can penetrate the blood-brain barrier, which is a protective barrier that limits the entry of chemicals into the brain. This enables more effective drug administration for the treatment of neurological disorders.
Fundamental Research: Nano-neuroscience advances fundamental research by giving instruments for studying the complicated molecular and cellular processes that occur in the nervous system. This research contributes to the understanding of the mechanisms behind neurological disorders and normal brain function.
Therapeutic Approaches: Novel nanotherapies are being investigated for the treatment of disorders such as brain tumors, neurological diseases (such as Alzheimer's and Parkinson's disease), and stroke. Nanoparticles can be used to deliver medications, DNA, or even stem cells to specific parts of the brain or spinal cord.
Ethical and Safety problems:The use of nanotechnology in neuroscience presents ethical and safety problems, specifically the possibility of unintended repercussions or unexpected risks when modifying neural systems at the nanoscale.
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Neurosurgery is a medical speciality that focuses on the surgical treatment of nervous system illnesses and ailments, including the brain, spinal cord, and peripheral nerves. Numerous advances in neurosurgery have been made throughout the years with the goal of improving patient outcomes, reducing invasiveness, and enhancing precision.
Here are some important neurosurgical breakthroughs:
Minimally Invasive Techniques: Neurosurgery has been transformed by less invasive techniques. Endoscopic brain surgery and minimally invasive spine surgery, for example, have smaller incisions, less tissue damage, and quicker recovery times.
Stereotactic radiosurgery: Techniques such as Gamma Knife and Cyber Knife enable surgeons to accurately deliver large doses of radiation to brain tumors or lesions without the need for open surgery.
Functional Neurosurgery: Deep brain stimulation (DBS) and responsive neuro stimulation (RNS) are functional neurosurgery procedures used to treat illnesses such as Parkinson's disease, epilepsy, and depression by implanting electrodes in specific brain areas and altering neural activity.
Neuro endoscopy: This procedure is used to treat problems such as hydrocephalus and some brain cancers. They utilize the use of a thin, flexible tube equipped with a camera to access and treat brain regions.
Intraoperative Imaging: Advanced imaging technologies, such as intraoperative MRI and CT scans, enable surgeons to see the brain and spinal cord in real time during surgery, improving precision and reducing the risk of complications.
3D Printing: 3D printing technology has permitted the development of patient-specific models and implants, increasing the precision of difficult surgeries and decreasing operative time.
Robot-Assisted Surgery: Neurosurgery has included robotics and automation to increase precision and dexterity in sensitive procedures such as tumor excision and spinal fusion.
Neuro prosthetics: Brain-computer interfaces (BCIs) and neuro prosthetic devices allow people with severe neurological disabilities to communicate and move by connecting the brain to external equipment.
Genomic Medicine: Genetic testing and customized medicine are increasingly being used in the diagnosis and treatment of neurological illnesses, allowing medications to be tailored to an individual's genetic profile.
Neurostimulation Devices: Implantable devices that modulate neural activity, such as spinal cord stimulators and vagus nerve stimulators, are used to manage chronic pain and neurological diseases.
Advanced Neuroimaging: Advances in neuroimaging, such as functional MRI (fMRI) and diffusion tensor imaging (DTI), provide insights into brain function and connection, assisting in surgical operation planning and monitoring.
Nanotechnology: Nanotechnology applications for drug delivery to the brain and the development of nanoscale devices that can interact with neurons for diagnostic and therapeutic purposes are being investigated.
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Neuroethics is an interdisciplinary discipline that investigates the ethical, legal, and social implications of neuroscience developments. It tackles questions and concerns about the use of neuroscientific information and technologies, as well as the ethical treatment of people whose brains are being studied or treated in clinical settings. Neuroethics is concerned with a wide range of issues, including:
Informed Consent: A crucial ethical aspect is ensuring that individuals engaging in neuroscience research or undergoing neurosurgery treatments completely understand the risks and benefits and freely give their informed consent.
Privacy: Advances in brain imaging and neurotechnology create worries about individuals' mental and neurological states being kept private. There are ethical concerns about who gets access to this information and how it should be protected.
Enhancement: The employment of neuroscientific procedures for cognitive improvement, mood modulation, or other objectives raises ethical concerns regarding justice and equity, as well as the possibility of societal pressure to enhance.
Neuroimaging and the Law: The use of brain imaging as evidence in court raises concerns about its reliability and the possibility of abuse, such as "neuroprediction" of criminal behavior.
Brain-Computer Interfaces (BCIs): While BCIs have the potential to increase human abilities, they also raise questions about privacy, autonomy, and unforeseen consequences.
Neurodiversity: This discipline explores the social and ethical aspects of understanding neurological diseases, opposes stigma, and promotes acceptance and support for neurodiverse people.
Brain Stimulation: The use of therapeutic treatments such as transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) raises ethical concerns concerning safety, consent, and the possibility of personality and identity changes.
Neuroscientific Behavior Explanations: Using neuroscience to explain human behavior might raise problems about individual responsibility, free will, and determinism.
Neuroethics in Education: When neuroscientific tools are employed for evaluation, intervention, or tracking student performance, ethical problems may arise.
Neuroscience and Identity: Understanding the neurological basis of personal identity and consciousness raises issues about the nature of self and personhood.
Global Health and Neuroscience: Ethical considerations in global health and neuroscience extend to questions of access to neuroscientific knowledge and tools, as well as the ethical conduct of research in international settings.
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Precision psychiatry, also known as personalized psychiatry or precision medicine in psychiatry, is a new approach to mental health care that strives to match the diagnosis, treatment, and prevention of psychiatric diseases to the particular characteristics of each patient. This approach emphasizes that mental health diseases vary greatly in terms of their underlying causes as well as their reactions to therapy. Precision psychiatry aims to use discoveries in genetics, neurology, and data analytics to deliver more effective, customized therapy for individuals suffering from mental illnesses.
The following are major components and concepts related to precision psychiatry:
Genomic and genetic Factors: Specific genes and genetic variations have been linked to an elevated risk of different mental health conditions, including depression, schizophrenia, bipolar disorder, and autism. Precision psychiatry is the use of genetic data to predict susceptibility to mental health disorders and guide treatment decisions.
Biomarker Discovery: Researchers are working hard to develop biomarkers, or measurable biological indications, that can aid in the diagnosis of psychiatric diseases, the monitoring of disease progression, and the prediction of therapy responses. Neuroimaging data, blood indicators, and other physiological parameters are examples of biomarkers.
Neuroimaging: Neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), have advanced, allowing clinicians to observe and examine brain function and structure. These methods can help guide treatment decisions by providing insights into the underlying neurobiology of psychiatric diseases.
Machine Learning and Data Analytics: Precision psychiatry depends on advanced data analysis tools, such as machine learning and artificial intelligence, to examine big datasets combining genetic, clinical, and neuroimaging data. These approaches can aid in the identification of trends and the prediction of individual treatment responses.
Tailored Treatment Plans: Precision Psychiatry strives to build individualized treatment programs based on an individual's unique genetic, neurobiological, and clinical profile, rather than using a one-size-fits-all approach to treatment. This may entail determining the best medication, counseling, or other therapies for a specific patient.
Early Intervention and Prevention: Precision Psychiatry also focuses on identifying individuals who are at risk of developing mental health illnesses before symptoms appear. Interventions can then be tailored to either prevent the disorder from developing or to lessen its severity.
Patient Involvement: Precision psychiatry frequently emphasizes the need of involving patients in treatment decisions and informing them about their own genetic and neurobiological traits. Patients who are better informed can take a more active role in their care.
Ethical Considerations: As with other aspects of precision medicine, there are ethical concerns about privacy, permission, and the potential misuse of genetic and neurobiological data. To protect patient rights, ethical rules and safeguards are required.
Research and Collaboration: Precision psychiatry is based on interdisciplinary collaboration between geneticists, neuroscientists, psychiatrists, psychologists, and other healthcare experts. Validation of biomarkers and treatment approaches also necessitates ongoing research.
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The altering or modulation of brain activity through various approaches and treatments is referred to as neuromodulation. In recent years, this sector has experienced considerable improvements, leading to new therapy methods for a variety of neurological and neuropsychiatric diseases.
Here are some of the most important neuromodulation techniques and their applications:
Deep Brain Stimulation (DBS): DBS involves implanting electrodes in specific parts of the brain and delivering electrical impulses to control neuronal activity. It has been used to treat diseases such as Parkinson's, essential tremor, dystonia, and obsessive-compulsive disorder (OCD). Ongoing study is looking into its potential for treating additional illnesses such as depression and epilepsy.
Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive technology that uses magnetic fields to stimulate specific sections of the brain's surface. It is an FDA-approved medication for depression and is also being studied for anxiety disorders, schizophrenia, and chronic pain.
Transcranial Direct Current Stimulation (TDCS): This technique includes applying a low electrical current to the scalp in order to regulate cortical excitability. It's being looked into as a possible treatment for depression, pain management, and cognitive enhancement.
Vagus Nerve Stimulation (VNS): To treat epilepsy and depression, a device that stimulates the vagus nerve is implanted. It's also being researched for its use in other ailments like anxiety disorders and Alzheimer's disease.
Spinal Cord Stimulation (SCS): SCS uses electrical spinal cord stimulation to treat chronic pain, particularly neuropathic pain syndromes such as failed back surgery syndrome and complicated regional pain syndrome.
Peripheral Nerve Stimulation (PNS): PNS is a technique that involves placing electrodes on peripheral nerves to relieve pain in disorders such as chronic migraine, peripheral neuropathy, and neuralgias.
Responsive Neurostimulation (RNS): RNS is a closed-loop device that monitors brain activity and delivers electrical stimulation in response to seizure activity. Its primary application is in the treatment of epilepsy.
Neurofeedback: Neurofeedback is a technology that uses real-time monitoring of brain activity, commonly electroencephalography (EEG), to give users with information about their brain state. It has implications in illnesses such as ADHD, anxiety, and post-traumatic stress disorder (PTSD) and can be used to train patients to self-regulate their brain activity.
Optogenetics: Optogenetics is a cutting-edge method that includes genetically altering neurons to make them light responsive. It enables researchers to selectively activate or inhibit certain brain circuits, which could lead to therapeutic applications in disorders such as Parkinson's disease, depression, and addiction.
Ultrasound Neuromodulation: Non-invasive ultrasonic techniques are being investigated in order to influence brain activity. When compared to other neuromodulation approaches, this technology has the potential for precision targeting and less adverse effects.
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The microbiome is the billions of microorganisms that live in various regions of the body, including the stomach, skin, and mouth cavity. Emerging evidence suggests a strong link between the gut flora and neurological health. The "gut-brain axis" relationship has consequences for a variety of neurological diseases and mental health.
Here are a few examples of how the gut microbiota can affect brain health:
Neurotransmitter Production: Gut bacteria can create neurotransmitters such as serotonin and dopamine, which are essential for mood regulation and brain function. Changes in the composition of the gut microbiota can influence the production of these neurotransmitters, thereby contributing to mood disorders such as sadness and anxiety.
Immune System Regulation: The gut microbiota is essential for immune system regulation. Multiple sclerosis and Parkinson's disease have both been linked to dysbiosis, or an imbalance in the gut microbiome. Chronic inflammation can harm neurons and hasten disease progression.
Metabolite Production: Gut bacteria digest food components and generate a variety of metabolites, some of which are neuroactive. Short-chain fatty acids (SCFAs) generated by gut bacteria, for example, have been proven to have neuroprotective properties.
Blood-Brain Barrier Integrity: The gut microbiota can affect the blood-brain barrier (BBB), which is a protective barrier that separates the bloodstream from the brain. A weakened BBB is linked to a variety of neurological diseases, and particular gut bacteria have been linked to its dysfunction.
Neurodevelopment: Emerging data suggests that the gut microbiome influences neurodevelopment in childhood. Microbiome disruptions during important developmental phases may lead to neurodevelopmental diseases such as autism spectrum disorder.
Stress Response: The gut-brain axis is also involved in the body's stress reaction. Stress can have an impact on the gut microbiota, and the gut microbiome can influence the body's reaction to stress. Dysregulation in this axis may contribute to stress-related diseases such irritable bowel syndrome (IBS) and post-traumatic stress disorder (PTSD).
Epilepsy and Seizures: Some research has suggested a link between the gut microbiome and epilepsy. Alterations in the gut microbiome composition may influence seizure susceptibility and response to antiepileptic medications.
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The COVID-19 pandemic, caused by the new coronavirus SARS-CoV-2, predominantly affects the respiratory system, but it can also impact the nervous system. According to new research, COVID-19 can cause a variety of neurological symptoms and problems.
COVID-19 has the following neurological consequences:
Smell and taste loss (Anosmia and Ageusia): The rapid loss of smell (anosmia) and taste (ageusia) is one of the most common neurological signs of COVID-19. These symptoms may appear early in the infection and may be among the earliest indications of COVID-19.
Headaches: Many COVID-19 patients describe headaches that range with intensity and length. Headaches may be caused by virus-related inflammation, fever, or other reasons.
Encephalopathy: Some people with severe COVID-19 develop encephalopathy, which is characterized by impaired brain function. Confusion, disorientation, and other cognitive problems might result from this.
Seizures: While seizures are uncommon, they have been reported in some COVID-19 patients. These seizures could be caused by the virus's direct influence on the brain or by fever and metabolic abnormalities.
Ischemic and Hemorrhagic Strokes: COVID-19 has been related to an increased risk of ischemic strokes (caused by blood clots) and hemorrhagic strokes (induced by bleeding in the brain). These strokes can develop in those who have severe COVID-19.
Neuropathy: Some patients have reported peripheral neuropathy symptoms such as tingling, numbness, and pain in the extremities. The processes at work are currently being studied.
Guillain-Barré Syndrome (GBS): GBS is a rare but deadly neurological condition linked to COVID-19. It is an autoimmune disorder in which the immune system assaults the peripheral nerves, causing weakening, numbness, and, in extreme cases, paralysis.
Meningitis and Encephalitis: Although uncommon, cases of viral meningitis (inflammation of the membranes protecting the brain and spinal cord) and viral encephalitis (inflammation of the brain) have been recorded in some COVID-19 individuals.
Psychiatric Symptoms: COVID-19 can also have psychological and psychiatric impacts, such as anxiety, depression, and post-traumatic stress disorder (PTSD), which might be considered neurological symptoms.
Long COVID and Brain Fog: Some people who have healed from acute COVID-19 continue to have neurological symptoms, which is known as "long COVID." This can include persistent brain fog, weariness, and cognitive impairments.
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Neurosurgery is a procedure that diagnoses and treats neurological disorders, injury and disease. Neurological surgery uses invasive techniques to investigate, diagnose and treat the neurological problem. This medical specialty treats any neurological disease which has affected any portion of the brain, peripheral nervous system (PNS), central nervous system (CNS), extra-cranial cerebrovascular system, and spinal cord.
A neurosurgeon is the individuals who have done their specialization course in neurosurgery. They learn how to treat various disorders on CNS, PNS, brain and spinal cord. Some important conditions treated by neurosurgeons are:
Some neurosurgery methods are:
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Market Analysis: Neurosurgery deals with the diagnosis and surgical treatment of the nervous system, which includes the brain, spinal cord, spine, and nerves. The global neurosurgery market is divided based on different product categories. Neurostimulation services, neurointerventional devices, cerebral spinal fluid (CSF) management devices, neurosurgical navigation systems, and other subsegments make up the product type segment. The greatest market for neurosurgery is in North America, followed by Europe. This is attributable to an increase in the number of patients with neurological disorders, the availability of technologically advanced neurosurgery equipment, increased research and development activities, increased public awareness of brain-related diseases, and enhanced regional healthcare infrastructure. In the coming years, Asia's neurosurgery market is predicted to rise at a rapid pace. The global neurosurgery market is expected to develop at a CAGR of 11.71 percent from 2014 to 2019.
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Pain disorder is in which patients suffer from extreme or chronic pain in one or more parts of the body. It is believed to be caused by psychological stress. Pain disorder is also classified as a mental disorder as a psychological factor plays important role maintenance, severity, and worsening of pain. Sometimes the pain is so severe it often refrains patients form proper functioning.
Pain disorder symptoms include hopelessness, despair feeling from intuition, sleep disturbance, fatigue, worsening of social and personal relationships, depression, anxiety, and disability. There are several causes of pain: trauma, abuse, emotions, psychodynamic theory, social causes, and communication. The behavior during pain put the psychological aspect of pain in the spotlight.
Pain disorders treatment or pain management involves sleep therapy, psychotherapy, and medication. Pain management center runs a pain control program, which is a multifaceted program using the blend of behavior, cognitive, group therapies to treat patients without conventional medical procedures.
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Market Analysis: An overwhelming majority of the world's population (85%) has suffered both head and body pain at some point in their lives, prohibiting people from fully living their lives, hurting their ability to parent, and negatively damaging their careers and social lives. In 2019, the global chronic pain treatment market was worth $77.8 billion, and it is predicted to increase at a 6.5 percent CAGR from 2020 to 2030. Because of increased government support for chronic pain treatment, the growing senior population, and the rising prevalence of chronic health disorders, the chronic pain treatment sector is booming.
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The nervous system getting affected by cancer is one of the severe conditions. The study of cancers of the nervous system is called Neurooncology. Neuro-Oncology is a branch of medicine concerned with the neoplasms of the brain and spinal cord. In the end, it becomes lethal in most cases. It does study, investigation, identification, and treatment for malignant and benign spinal cord and brain tumors.
Neuro-Oncology deals with various tumors like primary tumors of the Central nervous system (CNS) and metastatic tumors of CNS, and their numerous factors causing them at first place. Some worst cancer forms are gliomas of the pons, gliomas of the brainstem, glioblastoma multiforme, and astrocytoma.
The diagnosis of these brain tumors depends heavily on the diagnostic imaging or imaging of the brain. For diagnosis, Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are mainly used and other tests include Positron Emission Tomography (PET), Myelography and Angiography. The main treatment includes chemotherapy, surgery, radiotherapy, corticosteroids, cancer pain management, and neurosurgical interventions.
Neuro-Oncologists – they are the physician trained to investigate, interpret, diagnose and to treat patients with a brain tumor and tumors of the nervous system.
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Market Analysis: The global brain tumour medications market is estimated to increase at a compound annual growth rate (CAGR) of 6.3 percent from $1.89 billion in 2020 to $2.01 billion in 2021. In 2020, the market for Brain Tumors in the seven largest markets is expected to be worth USD 2,089.4 million. The United States has the largest market for brain tumours, with a market size of USD 986.0 million in 2020. Italy had the largest market size among the EU5 countries in 2020, with USD 214.4 million, while the United Kingdom had the smallest market size, with USD 129.8 million. In 2020, the Japan Brain Tumors market will be worth USD 256.7 million. This market is expected to increase at a CAGR of 10.4 percent over the forecast period, from USD 2.83 billion in 2021 to USD 5.64 billion in 2028.
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Neuroimaging is an essential part of diagnosis and to study in the area of Neurology and Neuroscience. It is an addition to a clinical and cognitive evaluation in the assessments of cognitive, behavioral and neurological disorders. Neuroimaging or brain imaging is to image the structure, function, and pharmacology of the nervous system mainly the brain and spinal cord.
Neuroradiologists are the one who specializes in neuroimaging techniques. Neuroimaging or brain imaging is a new discipline in medicine, neuroscience, and psychology to study the changes during various neurological and psychological conditions.
Neuroimaging can be classified into two major parts:
1. Structural Imaging: It deals with the structure of the nervous system and to diagnose intracranial disease and injury
2. Functional Imaging: It is used for research purposes: neurological and psychology and building brain-computer interface through cognitive neuroscience. It is also used to diagnose metabolic disease on a finer scale.
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Market Analysis: From 2021 to 2027, the global medical imaging market is predicted to increase at a CAGR of 3.99 percent, from USD 26.52 billion in sales in 2020 to USD 35.78 billion in 2027. Due to many driving factors, the worldwide medical imaging market is predicted to rise at a significant rate. The global medical imaging market is divided into X-Ray Systems, Ultrasound, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Others, based on imaging technique. The market is divided into hospitals, ambulatory centres, radiology centres, and others based on the end user. The global diagnostic imaging market is expected to grow at a CAGR of 5.7 percent from 2021 to 2026, from USD 26.6 billion in 2021 to USD 35.0 billion in 2026. The increasing demand for early disease diagnosis and the broadening scope of clinical applications, the rapidly growing geriatric population and the resulting increase in the prevalence of associated diseases, technological advancements in the diagnostic imaging industry, and increasing investments, funds, and grants by public-private organizations are all driving this market forward. In 2020, the global medical imaging market was worth USD 15.9 billion, and it is predicted to increase at a compound yearly growth rate of 5.2 percent until 2028.
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Stroke, a medical emergency, occurs when blood flow or arteries carrying blood to the brain is interrupted or blocked. It leads to a gradual decline of oxygen and nutrient in the brain leading to the rapid death of brain cells in minutes. Stroke is of two types: Ischemic, reduce blood flow and Haemorrhagic, internal bleeding. High blood pressure is one of the main risks of stroke and other risks include smoking, high cholesterol, obesity, and diabetes.
Signs of a stroke include paralysis, numbness, headache, trouble with speaking and understanding, confusion, and loss of coordination. Stroke diagnosis involves a physical exam to see balance, numbness, coordination, weakness or sign of confusion. Test through which we can diagnose stoke is MRI, CT scan, blood test, cerebral angiogram, echocardiogram, and carotid ultrasound. Prevention of stroke includes reducing the risks by doing exercise, controlling high blood pressure and diabetes, maintain a healthy weight, lowering the amount of cholesterol, taking anticoagulants or anti-platelet drugs.
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Market Analysis: Stroke is a medical emergency that occurs when blood supply to the brain is reduced, and brain cells begin to die as a result.The global stroke management market was worth $22,581 million in 2016, and it is expected to expand to $36,756 million by 2023, with a CAGR of 7.1 percent over the forecast period (2017-2023).A stroke is a medical emergency that occurs when the blood supply to the brain is cut off, causing brain cells to die. The global stroke management market is estimated to reach $36.7 billion by 2023, with a 7.4 percent compound annual growth rate (CAGR) over the forecast period.
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Epilepsy, a chronic disorder, is a central nervous system disorder in which seizures occur frequently. In epilepsy, brain activity becomes abnormal leading to recurrent seizures, unusual behavior, loss of awareness, and sensations. Epilepsy can happen to anyone irrespective of gender, race, and age.
The major symptom of Epilepsy is seizures. There are mainly two types of seizures: focal seizure and generalized seizure. The other symptoms include the sudden fall of a person with no reason, unresponsiveness, and convulsion with no temperature, inappropriate repetitive movements, blackout, and confused memory. Epilepsy caused by the effect of genes or the surrounding environment. Acquired epilepsy causes include stroke, tumors, brain trauma, and infection in the brain. The genetic cause of epilepsy is more common among young people and in older people, brain tumors and stroke are more common. The exact cause of Epilepsy in most of the cases is unknown.
Epilepsy can be observed by electroencephalogram, computed tomography (CT) scan, magnetic resonance imaging (MRI), and neuroimaging. These techniques can give a better picture to understand the abnormalities of the brain during a seizure, and to look at the minute changes in the structure of the brain.
There is no proven cure of epilepsy, being alert and proper care the consequences of epilepsy and seizures can be averted. Some antiepileptic drugs are in the market to keep seizures in check. We can reduce the chance of seizures by a healthy daily routine.
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Market Analysis: In the projection period of 2021 to 2028, the epilepsy market is predicted to increase at a rate of 7.78 percent. The expansion of the epilepsy market is accelerating due to an increase in epilepsy awareness. By 2023, the Epilepsy Market is expected to be worth USD 9.50 billion, with a CAGR of 8.20 percent over the forecast period (2018-2023). The rising prevalence of epilepsy in the senior population, as well as an increase in accident-related brain injury cases, are driving market expansion. The epilepsy market has been developing at a healthy rate in recent years, and it is predicted to rise at a CAGR of 7.36 percent from 2021 to 2028. The rise in the number of accidents and brain injuries, as well as the greater rate of post-traumatic seizure occurrence in patients with brain injuries, is driving the Global Epilepsy Market. The Global Epilepsy Market research offers a comprehensive analysis of the industry.
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Multiple Sclerosis (MS) is a chronic, unpredictable disease that leads to the loss of information exchange in the brain and between the brain and body. MS affects the central nervous system principally spinal cord, optic nerves, and the brain. In Multiple Sclerosis, damaging of insulating covers of nerve cells by demyelinating of these covers in the brain and spinal cord.
In MS, symptoms are like numbness, tingling, dizziness and fatigue, sexual dysfunction, muscle weakness, ataxia, acute or chronic pain, change in sensation, vision problems, tremor, memory problems, and muscle spasms. Signs and symptoms may vary in MS and it depends on the level of the damage to nerve cells.
Multiple Sclerosis is an autoimmune disorder, in which the immune system attacks the myelin sheath which protects the nerve cells leads to communication problems in the body. The main cause behind this is not yet found. But it is believed that it is a result of accumulated genetic and environmental factors. Some cause may be genetic, geographical, infection, and acquired factors as well.
Multiple Sclerosis has no cure. Medication helps to prevent new attacks or to stabilize functioning after an attack.
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Market Analysis: The global market for multiple sclerosis (MS) medicines was worth $22.99 billion in 2018, and is expected to reach $28.00 billion by 2026, with a CAGR of 2.5 percent between 2019 and 2026. Multiple sclerosis is a chronic inflammatory disease that causes demyelination, axonal transection, and neurodegeneration in the brain and spinal cord's nerve cells. The global market for multiple sclerosis medications is valued at $27.38 billion in 2021 and is predicted to grow at a CAGR of 6.3 percent to $41.99 billion in 2028. MS affects around 57.8 people per 100,000 in the United States. The prevalence is stated to be 68.8 per 100,000 above the 37th parallel and 35.5 per 100,000 below it. Scientists are still working hard to develop new and improved treatments for MS. By 2028, the global market for multiple sclerosis drugs will be valued $ 42.46 billion, with a 6.3 percent compound annual growth rate.
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Alzheimer's disease is a neurodegenerative disorder that leads to the death of brain cells. It progresses over time and worsens at the end. Alzheimer's is the cause of 60-70% of dementia. Dementia is a neurological condition in which the ability to think and remember small things becomes so severe that is starting to affect their daily routine.
The most common symptoms of Alzheimer's and dementia are forgetting becomes very often, difficulty in remembering some events occurs, and in some severe cases, patients suffer difficulty in remembering recent events and conversations. Alzheimer's disease and dementia patients develop hindrances in making judgments, reasoning, thinking, decision and performing daily tasks.
The precise cause of Alzheimer's and dementia are not fully understood but most of the researchers think that it is a result of various factors: genetics, environmental, and lifestyle. The risk factors associated with Alzheimer's and dementia are age, syndrome, sex, trauma, lifestyle, social engagement, and family genetics.
As these diseases are progressive, not even a single cure proves to revert this process. Patients affected with this disease need help from others.
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Market Analysis: The Alzheimer's disease diagnostics and therapeutics market was worth USD 6,632.82 million in 2020, and it's predicted to grow to over USD 9,073 million in 2026, with a CAGR of nearly 5.36 percent from 2021 to 2026. The rising frequency of chronic diseases such as dementia, as well as increased pipeline drug research, investment in biomarkers for drug development, and better diagnostics for early detection, are all driving this industry forward.According to the World Alzheimer Report, over 50 million individuals worldwide suffer from Alzheimer's disease and related dementia in 2019, with that figure anticipated to rise to 152 million by 2050. Alzheimer's disease is thought to afflict up to 6% of the population over the age of 65. With the discovery of some therapeutic procedures and the rising frequency of Alzheimer's disease, there are markets for Alzheimer's treatments. The growing number of people over the age of 65 is partly to blame for the rising incidence of Alzheimer's disease. Although there have been occasional cases of young-onset Alzheimer's, which is defined as Alzheimer's symptoms in adults under the age of 65, this is rare.
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Case studies can be defined as the intensive study of any particular individual, community or group in which the researcher analyses several variables to derive a conclusion. Case studies are the best way to study any particular field by getting a practical overview of the respective case. Case studies do not have any set of procedures to follow. It helps another person to gain practical knowledge and help them to enhance or improve their own ability to perform the same task with better precision.
Clinical trials are the study that concludes how safe the treatments, tests, and medicine are.
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Market Analysis: The global market for neurology clinical trials is expected to reach USD 7.4 billion by 2028, according to a new study by Grand View Research, Inc. The market is expected to increase at a 5.5 percent CAGR between 2021 and 2028. This is due to big pharma companies conducting new neurology trials, increased government financing from the National Institute of Neurological Disorders and Stroke (NINDS), and strict regulatory standards for clinical trials. The global market for neurology clinical trials is expected to reach USD 7.4 billion by 2028. From 2021 to 2028, the market is estimated to grow at a CAGR of 5.5 percent. Neuroscience continues to attract a good amount of early funding. In 2018, it attracted USD 1.5 billion in venture capital funding, second only to cancer, indicating that investors believe a huge pharma acquisition will pay off soon. Early detection of diseases is attracting investment and driving dealmaking in the complex neuroscience sector, particularly for pain and Alzheimer's disease, as the industry attempts to move past the many late-stage clinical failures of recent years.
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These are the approach taken to eradicate or treat a particular disease. Neurology integrated with neuroscience provides an ample amount of useful data to innovate or develop new ways of treatment of various neurological diseases and disorders.
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Market Analysis: The global neurology market is expected to increase at a compound annual growth rate (CAGR) of 3.5 percent from $33.3 billion in 2019 to $39.4 billion in 2024.
Between 2018 and 2028, the global market for rare neurological illness treatments is expected to increase at an impressive CAGR of over 8.5 percent, growing 2.3 times. The incidence of rare diseases, the evolving trend of orphan pharmaceuticals, and rising healthcare spending have all contributed to a significant increase in overall sales of rare neurological treatments during the previous decade. As a result, global sales in the uncommon neurological illness treatment market reached a new high in 2019, surpassing the US$ 6.5 billion mark. Furthermore, the rare neurological disease treatment market is expected to be the most attractive market among the rare illness treatment markets, owing to their comparatively high market value share and growth rate. On the back of rising demand for orphan pharmaceuticals, ongoing research and development activities in the field of rare neurological illness therapy are multiplying. Between 2018 and 2028, this is expected to generate an absolute monetary potential of US$ 8.1 billion.
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Headache is describes as a painful sensation in any part of the head, the pain can be dull or sharp and it may also occur with other symptoms. Headache and facial pain are common complaints in OPD facilities. Headaches are treated with medication, stress management and biofeedback.
Trigeminal neuralgia is the most common term associated with a chronic facial pain condition that affects the trigeminal nerve, which carries sensation from face to brain. Trigeminal neuralgia pain most commonly affects only one side.
Primary headaches are those that aren’t due to any underlying medical condition. It includes
Cluster headaches.
Migraine.
New daily persistent headaches (NDPH).
Tension headaches.
Secondary headaches are mostly symptoms of other diseases, such as:
Disease of blood vessels in the brain.
Head injury.
High blood pressure (hypertension).
Infection.
Medication overuse.
Sinus congestion.
Trauma.
Tumor.
Market Analysis: In the foreseeable term, the migraine market is expected to rise at a considerable CAGR. .Migraine is a medical disease in which people suffer from intense headaches. From 2018 to 2025, the global migraine medications market is predicted to increase at a CAGR of 3.1 percent, from $1,713 million in 2017 to $2,190 million in 2025. Migraine medicines are used to treat headaches that are caused by migraines.
Anti Migraine Drugs Market size is expected to reach $10.56 billion by 2025, with a CAGR of 9.7% over the forecast period of 2020-2025.
Around 15% of people worldwide suffer from migraine, and the market will be driven by growing use of anti-migraine drugs during the projected period.
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Early diagnosis and proper screening of neurological disorders is the key for better prognosis and cure. Investigating the damage caused to the nervous system is extremely complicated and complex. Most of the similar symptoms happen in different disorders. There are many disorders which doesn't have definitive causes, markers, or tests, that makes a diagnosis even harder.
To confirm a neurologic condition such as brain injury, tumors, hydrocephalus, aneurysm, epilepsy or stroke, a range of neurologic tests are performed.
Sub-track
Market Analysis: Several neurological disorders, such as Multiple Sclerosis, Alzheimer's disease (AD), and Parkinson's disease, are diagnosed with neurological disorder diagnostic instruments (PD).
Furthermore, the recent rise in the prevalence of neurological disorders is expected to drive the global neurological disease diagnostic market.
The neurodiagnostics market is estimated to grow at a CAGR of 7.3 percent from USD 5.9 billion in 2019 to USD 8.4 billion in 2024.
The growing prevalence of neurological disorders and diseases, technological advancements, growing patient emphasis on effective and early disease diagnosis, the growing number of diagnostic centres and hospitals, and the use of biomarker profiling for disease diagnostics are all expected to drive demand for neurodiagnostics products. The global neurological biomarkers market was valued at USD 6.1 billion in 2020, with a compound annual growth rate (CAGR) of 12.9 percent predicted from 2020 to 2028. Furthermore, technological improvements are fueling market expansion by increasing the requirement for early identification of neurological illnesses.
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Neuropharmacology refers to the study of the effects of drugs on the nervous system, this field involve the study and research on the actions of medications for psychiatric and neurologic disorders as well as those of drugs of abuse. Neuropharmacology also uses drugs as tools for better understanding of normal nervous system functioning. The main objective of neuropharmacology is to apply mechanisms of drugs to develop effective treatments and preventive measures for nervous system abnormalities. It helps to understand how drugs affect cellular function in the nervous system. Behavioral and molecular are the two different parts of neuropharmacology . Behavioral neuropharmacology focuses on the study of how drugs affect human behavior and molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with an aim of developing drugs that helps in improving neurological function.
The study of neurotransmitters, psychopharmaceuticals and neuropeptides, that control and influence the physiology of the nervous system is known as Neurochemistry. Research in this field is focused on the biochemistry and molecular biology of organic compounds in the nervous system, and their roles in neural processes like cortical plasticity, neurogenesis, and neural differentiation. Neurochemicals are basically oxytocin, serotonin, dopamine and other neurotransmitters and neurotransmitter-regulating substances. This particular field investigates how neurochemicals influence the operation of neurons, synapses, and neural networks.
Market Analysis: Pharmaceuticals are one of the most valuable endeavours on the planet. In 2008, the pharmaceutical industry sold $773 billion in goods around the world, a figure that has been consistent for up to 8 years and is expected to rise by 2.5 to 3.5 percent in 2017. By 2025, the global pharmaceutical market is expected to reach $10.27 billion USD. The pharmaceutical market is expected to grow from just over $22.85 billion in 2016 to $25.2 billion in 2020, with a compound annual growth rate (CAGR) of 2%. It is expected to reach USD 2,151.1 billion by 2027, growing at a CAGR of 7%.
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The term neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products. Research in this field in going on to understand the basic mechanisms involved in neurodegeneration or neurologic injury. However, due to the complex structures of the nervous system, the regeneration process becomes extremely challenging. The brain, spinal cord and peripheral nerves which are susceptible to various types of injury ranging from trauma to neurodegenerative diseases that cause progressive deterioration is unfortunately often irreversible, and a very little spontaneous regeneration, repair or healing occurs.
Stem cell therapies hold promising future in terms of neurological treatment. Neural stem cells (NSCs) has the potential to replace lost tissue after nervous system injury. Hence, stem cells can promote host neural repair in part by secreting growth factors. Stem cells holds a great promise for treating many neurological disorders, researches showed that it can reduce the total damage to peripheral nerves and improving tissue regeneration. Neurological disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and spinal cord injury are caused by a loss of neurons and glial cells in the brain or spinal cord.
Researchers have successfully generated neurons and glial cells from stem cells.Investigators have done extensive research to develop and carry out stem cell-based brain transplantation therapies.Stem cell research is in progress for the development of novel therapies to cure a wide range of neurological disorders.
Market Analysis: The primary drivers driving the market's growth are an increase in stem cell research and approvals of GMP certified facilities. For the years 2021-2026, the overall market development of the Stem Cell Marker is expected to be boosted by rising demand for gene treatments and the rising prevalence of chronic diseases. In 2020, the worldwide stem cell industry is expected to produce USD 9.38 billion in sales. From 2021 to 2028, it is predicted to increase at a compound annual growth rate (CAGR) of 8.8%. The global stem cell therapy market is expected to grow at a CAGR of 16.5 percent to USD 401 million by 2026, up from USD 187 million in 2021. Factors such as expanding stem cell research activities and increasing approvals of GMP-certified facilities to generate stem cells are driving market expansion. The global stem cell therapy market is predicted to increase at a compound annual growth rate (CAGR) of 18.3 percent from $8.62 billion in 2020 to $10.2 billion in 2021.
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Operations on the bones, discs, and soft tissues of the spine with the goal of reducing pressure on the spinal cord or spinal nerve roots, or the removal of masses inside the spine, are referred to as spinal neurosurgery. Pressure on the lower spinal nerve roots in the lumbar spine or the upper spinal nerve roots in the cervical spine is the most common reason for considering spinal neurosurgery. This frequently occurs in the foramen, which is the region where the nerves exit the spine and are held. Spinal stenosis is a word used to describe an issue that occurs in the space known as the central canal.Unfortunately, resecting masses from around the spinal cord or within the dura itself is another rationale for spinal neurosurgery. These masses may not be cancerous, but because they can compress the spinal cord, they are frequently treated using spinal neurosurgery.
Sub-tracks:
• Degenerative Diseases
• Spinal Deformity and Malformations
• Vertebral Tumors
• Spin injury and Trauma
• Spinal Infectious Diseases
• Craniocervical Junction Anomalies
• Spinal Cord Tumors
• Intradural Extramedullary Spinal Tumors
Market Analysis : The developments in spine surgery technologies, the rising frequency of spinal illnesses, the introduction of enhanced bone grafting materials, and the growing use of minimally invasive spine procedures are all driving the global spinal surgery market. However, the high cost of spinal surgery and reimbursement uncertainty are projected to limit market expansion throughout the projection period. The market for spinal surgery devices was valued at around USD 9,350 million in 2020, and it is predicted to reach USD 12,245 million in 2026, with a CAGR of nearly 4.50 percent from 2021 to 2026.
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Pediatric neurosurgery is a branch of neurosurgery that treats children with operable neurological problems. It involves surgical treatments involving the nervous system, brain, and spinal cord. Pediatric neurosurgeons work with children from the time they are born until they reach adolescence. They have chosen to make paediatric care the centre of their medical practise, and they have understood the particular nature of paediatric medical and surgical care via extensive training and practise. Pediatric neurosurgeons deal with a variety of neurosurgical issues that aren't always the same as those addressed by adult or general neurosurgeons. It is critical to have specialised expertise in paediatric disorders as they pertain to paediatric neurosurgery problems.
Sub-tracks:
• Hydrocephalus and CSF Dynamics
• Cranial congenital malformations
• Spinal dysraphisms
• Supratentorial Tumors
• Posterior Fossa Tumors
• Spinal Tumors
• Pediatric Trauma
• Pediatric Vascular Diseases
Market Analysis : In the projected period of 2021 to 2028, the global paediatric neurosurgery market is expected to increase at a CAGR of 6.20 percent, reaching USD 2,794.36 billion. The increased awareness of the importance and benefits connected with the usage of paediatric neurosurgery among people and patients has had a direct impact on the growth of the worldwide paediatric neurosurgery market.
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Points within the brain are located using an external, three-dimensional frame of reference, usually based on a Cartesian coordinate system, in functional neurosurgery. Because the disease paradigms handled in functional neurosurgery are continually changing and evolving, it stands out among other neurosurgical disciplines. The basic idea is that functional neurosurgery does not necessarily treat a structural issue, but rather alters central nervous system circuits to bring about a change within or outside the nervous system. This is a strong indication of the breadth of functional neurosurgery's use. Movement disorders such as Parkinson's disease, essential tremor, and dystonia have been transformed through functional neurosurgery.Advances in the understanding of the physiology of the target structures and the pathophysiological underpinnings of movement problems have occurred concurrently with the development of deep brain stimulation. In order to influence brain function, functional neurosurgery entails careful surgical targeting of anatomic components. The technique of stereotactic neurosurgery is used to locate surgical targets within the brain in relation to an external frame of reference. The term "stereotactic" refers to the accurate location of objects deep within the brain using a three-dimensional coordinate system and an imaging technique such as computed tomography scanning or magnetic resonance imaging. Other neurosurgical operations, such as the biopsy of deep brain tumours, frequently employ these techniques.
Sub-tracks:
• Deep brain stimulation for movement disorders
• Epilepsy
• Pain
• Spasticity
• Neuromodulation
• Restorative Techniques
Market Analysis : The surgical speciality of neurosurgery deals with the diagnosis and surgical treatment of the nervous system, which includes the brain, spinal cord, spine, and nerves. A neurosurgeon is a doctor who specialises in neurosurgery. The global neurosurgery market was worth $3.9 billion in 2020 and is predicted to reach $4.57 billion by 2025, with a CAGR of 5.8%. Medtronic, Boston Scientific Corporation, Stryker, Conmed Corporation, and Smith & Nephew are the market's major participants. The rising incidence of neurological disorders, efforts to expand the application base for neuromodulation, the advantages of neuroendoscopic procedures over traditional brain surgeries, and the growing prevalence of neurological diseases all contribute to the market's growth.
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Blood vessels that are damaged, injured, or deformed can cause bleeding or circulation difficulties, which can lead to strokes, headaches, and other symptoms. Neurovascular surgery treats abnormalities with the blood arteries of the brain, spine, and spinal cord using open or minimally invasive surgical procedures. The subject of neurovascular surgery is becoming increasingly complicated and technological, embracing classic surgical approaches as well as endovascular and neurointerventional techniques. Clinicians in the Neurovascular programme specialise in the treatment of all vascular disorders of the brain and spinal cord using a variety of therapeutic strategies such as surgery, endovascular interventional treatments, stereotactic radiation, and rehabilitation.
Sub-tracks:
• Aneurysms and Subrachnoid Hemorrhage Pathophysiology
• Arteriovenous Malformations
• Cerebral Ischemia and Revascularization
• Spontaneous Intracerebral Hemorrhages
• Endarterectomy
• Endovascular Neurosurgery
• Open Neurovascular Surgery
• Hybrid Surgery & Advanced Technology
• Cerebrovascular Surgery
• Ischemic Stroke and Vascular Insufficiency
• Cerebral and Spinal Aneurysms
• Cerebral and Spinal Arteriovenous Fistulae and Malformations
• Vascular Tumors
• Revascularization techniques
• Vascular Stereotactic Radiosurgery
Market Analysis : The market for neurovascular devices and interventional neurology is predicted to increase at an annual rate of 8.6% from USD 2.5 billion in 2021 to USD 3.8 billion in 2026. The market for neurovascular devices is likely to be driven by the rising frequency of neurological illnesses, technical developments, and the growing desire for minimally invasive operations. Interventional neurology devices are used to diagnose and treat brain and central nervous system vascular disorders. Interventional neurology entails a variety of procedures. From 2021 to 2030, the Neurovascular Devices Market is expected to develop at a compound annual growth rate (CAGR) of 5.7 percent, reaching US$ 4.52 billion.
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The use of electrophysiological technologies to monitor the functional integrity of particular brain regions during surgery is known as intraoperative neurophysiological monitoring (IONM) or intraoperative neuromonitoring. During the procedure, various intraoperative neurophysiological monitoring techniques evaluate the function of the brain, brainstem, spinal cord, cranial nerves, and peripheral nerves. They are extremely useful in detecting and preventing brain injury. Intraoperative monitoring is increasingly commonplace in medical practise, and it's used to assess the risk of brain impairment during a variety of surgical operations. IONM makes use of a wide range of physiological principles, each with its own set of applications that are frequently combined in the same procedure to improve patient outcomes.The adoption of various neuromonitoring techniques throughout the extra surgical procedure has increased as the benefits of monitoring became clear. IOM has been used to try to avoid or reduce substantial postoperative deficits by minimising neurological injury during surgery, identifying critical brain structures in the operational field, and so on.
Sub-tracks:
• Neuromonitoring
• Electroencephalography (EEG)
• Electromyography (EMG)
• Somatosensory evoked potential (SSEP)
• Motor evoked potential (MEP)
• Brainstem auditory evoked potential (BAEP)
• Visual evoked potential (VEP)
Market Analysis : Intraoperative neurophysiological monitoring is a group of treatments used to monitor neural pathways during high-risk neurosurgery, orthopaedic, peripheral nerve, and vascular procedures. It is primarily used to minimise the risk of neurological impairments following nervous system surgeries. By 2025, the market for intraoperative neuromonitoring (IONM) is expected to grow at a CAGR of 6.5 percent. The rising incidence of various lifestyles linked to chronic diseases such as neurological and cardiovascular problems, as well as an increased focus on patient safety during intricate surgeries, are projected to fuel market growth.
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The peripheral nervous system (PNS) is a network of 43 motor and sensory nerves that connects the brain and spinal cord (the central nervous system) to the rest of the body. The brain and spinal cord are connected to the rest of the body by peripheral nerves. Peripheral nerve problems damage one or more nerves and can impair communication from the brain to the rest of the body. People with peripheral nerve problems, such as acute nerve injuries, entrapment neuropathies, and nerve sheath tumours, undergo peripheral nerve surgery to restore function and reduce pain and impairment. It entails rerouting healthy nerves to take over the function of nerves that have been damaged, diseased, or otherwise compromised by your injury, disease, or condition.43 pairs of peripheral nerves extend from the spinal cord, similar to electrical lines, and provide movement, motor coordination, and sensation throughout the body. Carpal tunnel syndrome, ulnar nerve compression, peroneal nerve compression in the knee, meralgia parasthetica, and tarsal tunnel syndrome are the most common problems of this sort. Surgery works wonders for nerve entrapment. Recovery is swift, and patients can resume their normal routines.
Sub-tracks:
• Traumatic nerve injury
• Carpal tunnel syndrome and surgery
• Thoracic outlet syndrome
• Ulnar nerve neuropathy
• Guillain-Barre syndrome
• Schwannoma and Neurofibroma
• Brachial plexus surgery
• DREZ procedure
• Nerve repair or nerve graft
• Nerve entrapment surgery
• Nerve sheath tumor surgery
• Nerve transplant surgery
• Open decompression surgery
Market Analysis : From 2017 to 2023, the global Nerve Repair and Regeneration Market is expected to increase at a CAGR of 13.0 percent, from $5,927 million in 2016 to $13,938 million in 2023. Peripheral Nerve Repair market size was USD 135.3 million in 2015, and it is predicted to grow at a CAGR of 20.8 percent to USD 514.9 million by the end of 2026. The high frequency of nerve injuries, expanding prevalence of neurological disorders, growing elderly population, and increased government support for neurologic disorders are driving this market's expansion.
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Robotics is a fast-moving discipline that is changing neurosurgery in combination with breakthroughs in artificial intelligence and machine learning. Robotic surgery has the potential to eliminate mechanical errors, save operating hours, and give the same or better resective margins than minimal-access surgery. This will result in great surgical outcomes with the fewest possible problems. Because of the physical complexity of the brain and the space limits inherent in neurosurgical procedures, we can observe some encouraging steps in this direction, but there is still a long way to go. The NeuroMate robot was the first FDA-approved robotic equipment intended exclusively for neurosurgery usage. There are various robotic technologies available for spinal surgery that provide tool guiding and implant placement confirmation.ROSA Brain, an advanced surgical tool, is used in robot-assisted neurosurgery to do minimally invasive surgeries in the brain. Robotic operating surgical assistant (ROSA) is an acronym for robotic operating surgical assistant. It combines a robotic arm with the ability to take comprehensive brain images of your child.
Market Analysis : Robotic neurosurgery is a rapidly evolving technology that offers a number of advantages over traditional neurological surgery, including improved outcomes, enhanced accuracy, faster recovery, and a shorter hospital stay, to name a few. From 2020 to 2030, the number of surgeries performed with robotic surgical systems in the United States will increase at a CAGR of 10.5 percent. The growing incidence of neurological diseases, ageing population, improved benefits with robotics-based procedures, and decreasing price of robot-assisted neurology surgery will drive the global neurosurgical robotics market to $2,010.7 million by 2027, growing at a 16.8 percent annual rate from 2020 to 2027. Surgical robots allow surgeons to perform more precise difficult surgical procedures. Furthermore, the introduction of new and advanced robots will meet the ever-increasing demands of end users.
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The term "brain surgery" is a catch-all term for a variety of medical operations involving the treatment of structural problems in the brain. Head and brain surgery is a very difficult procedure. Tumors, blood clots, aneurysms, epilepsy, and Parkinson's disease are among the disorders for which brain surgery is utilised. There are several different kinds of brain surgery. The type of treatment depends on the brain area and the condition being treated. Surgeons can now operate on parts of the brain without making a single incision in or near the head because to advances in medical technology. Brain surgery is used to treat physical problems with the brain. These can be caused by a birth flaw, a disease, an injury, or a variety of other issues.
Sub-tracks:
• Biopsy
• Craniectomy
• Minimally invasive endonasal endoscopic surgery
• Stereotactic radiosurgery
• Endoscopic brain surgery
• Laser interstitial thermal therapy
• Deep brain stimulation (DBS)
• Craniotomy
• Posterior fossa decompression
• Thrombectomy and cerebral aneurysm repair
Market Analysis : The global market for brain surgery is expected to increase at a CAGR of 12.9 percent from $1.1 billion in 2018 to $2.0 billion in 2023. Neuroendoscopy is an advanced brain surgery method in which the neurosurgeon uses an endoscope to navigate and access the tumour. Neurosurgeons attach specific devices to the endoscope, frequently an additional endoscope with forceps and scissors on the end, to remove a tumour or take a sample of it, as opposed to traditional open brain surgery, which takes longer to heal and causes less discomfort. Up to 2025, the neuroendoscopy market is expected to grow at a rate of about 4.6 percent.
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The face and the cranium, which surround the brain, are made up of bones and cartilage that make up the skull. The base of the skull is a busy and convoluted location with numerous openings through which the spinal cord, numerous blood arteries, and nerves all travel. Noncancerous and cancerous growths, as well as anomalies on the underside of the brain, the skull base, or the top few vertebrae of the spinal canal, may be removed by skull base surgery. Skull base surgery is a form of specialty surgery that treats problems at the base of the skull. Reaching these locations without cutting through the skull and retracting the brain is a problem in skull base surgery.
Sub-tracks:
• Pituitary tumors
• Meningiomas
• Chordomas and Schwannomas
• Trigeminal neuralgia
• Vestibulocochlear nerve disorders
• Craniopharyngiomas and Pineal Region Tumors
• Hemifacial spasms
• Craniostenosis
• Cerebro-spinal fluid fistulas
• Cerebral aneurysms
• Arteriovenous Malformations (AVMs)
• Approaches and Reconstructive Techniques
• Endoscopic Techniques Traditional or open skull base surgery
• Endoscopic or minimally-invasive skull base surgery
• Advanced Microscopic, Laser and Ultrasonic Techniques
Market Analysis : In the market for skull base therapy, endoscopic approaches have played a significant role. In the projected period of 2021 to 2028, the surgical endoscopes market is expected to increase at a CAGR of 6.1 percent, reaching USD 4,185.80 million. The growing preference for minimally invasive surgeries is propelling the surgical endoscope market forward. From 2021 to 2028, the global endoscopy devices market is predicted to increase at a compound annual growth rate (CAGR) of 7.3 percent. One of the primary factors driving the market is the shift in the trend of healthcare professionals and patients switching from traditional open surgeries to minimally invasive procedures.
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A abrupt injury to the head or spine causes neurotrauma. Concussions, traumatic brain injuries, skull fractures, spinal column fractures, and spinal cord injuries are all part of this category. Traumatic brain injury can be classified as either primary or secondary, depending on whether it is caused by the force associated with the neurotrauma or develops as a result of the neurotrauma. Neurotrauma is still a leading source of morbidity and mortality in the United States. Primary neurologic injury prevention is a major public health priority. The goal of critical care for a patient who has suffered a neurotrauma is to prevent further damage. Potential neuroprotection medicines still require a lot more investigation.
Sub-tracks:
• Mild TBI, Blast Injuries and Sports-related Concussion
• Moderate to Severe TBI
• Chronic Subdural Haematoma
• Traumatic Spinal Cord Injury
• Neuro Intensive care
• Preclinical studies
• Pediatric trauma
• Quality assessment
• Patient safety
• Rehabilitation
• Prehospital management
• Neuroimaging
• Neurocritical Care for TBI and SCI
Market Analysis : Treatment for neurotrauma is a long-term commitment. The global market for non-invasive brain trauma monitoring devices is estimated to reach USD 16.99 billion by 2026, growing at a 7.7% CAGR. The use of non-invasive brain trauma monitoring devices in neurotrauma and other brain illnesses is expected to drive the market. According to the report, the worldwide critical care equipment market is expected to increase at an annual rate of 8.7% from 2019 to 2025. Critical care equipment in intensive care units is designed to provide round-the-clock care and monitoring.
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Neuroimaging techniques are used in the field of radiology known as neuroradiology to recognise and categorise abnormalities of the spine, head and neck, and central and peripheral nervous systems. Neuroradiology has the ability to identify a variety of medical disorders, including arteriovenous malformations, tumours, aneurysms, and strokes.
Neuroradiology is becoming more important in the diagnosis of neuropathologic illnesses as current technology develops. Cross-sectional imaging, particularly computed tomography (CT) and magnetic resonance (MR) imaging, has revolutionised diagnostic procedures for disease of the central and peripheral nervous systems.
Modern, sophisticated imaging techniques like functional MRI, diffusion tensor imaging, and perfusion imaging can provide extra, helpful information that can aid in diagnosis and therapy response monitoring. Therefore, the neuroradiologist and neuropathologist should collaborate to provide knowledge that is clinically useful. The practising neuropathologist can tremendously benefit from being conversant with neuroradiology imaging tests and fundamental neuroimaging patterns.
Market Analysis: The market for interventional neuroradiology has shown steady expansion over the past few years, and it is anticipated that the market will expand significantly from 2020 to 2027.
The global market for radiology was valued at USD 26.6 billion in 2021 and is anticipated to grow to USD 43.04 billion by 2029, displaying a CAGR of 6.20% over the forecast period of 2022-2029.
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