Title: Transcriptome analysis of large to giant congenital melanocytic nevus reveals cell-cycle arrest and immune evasion: Identifying potential targets for treatment

Abstract

Background: Large to giant congenital melanocytic nevus (lgCMN) are cutaneous benign tumors that develop during embryogenesis. A large number of lgCMN patients are ineligible for surgical treatment, hence the urgent need for developing pharmacological treatment. Clinically, tumorigenesis and progression mostly come to a halt after birth, resulting in homeostasis of growth arrest and survival. Numerous studies on whole-genome or whole-exome sequencing in lgCMN have been reported to clarify its etiology. However, transcriptome sequencing is still lacking in lgCMN. Objective: Through comprehensive transcriptome analysis, this study aimed to elucidate the ongoing regulation and homeostasis in lgCMN and identify potential targets for treatment.