Title: Transcriptome analysis of large to giant congenital melanocytic nevus reveals cell-cycle arrest and immune evasion: Identifying potential targets for treatment

Abstract

Background: Large to giant congenital melanocytic nevus (lgCMN) are cutaneous benign tumors that develop during embryogenesis. A large number of lgCMN patients are ineligible for surgical treatment, hence the urgent need for developing pharmacological treatment. Clinically, tumorigenesis and progression mostly come to a halt after birth, resulting in homeostasis of growth arrest and survival. Numerous studies on whole-genome or whole-exome sequencing in lgCMN have been reported to clarify its etiology. However, transcriptome sequencing is still lacking in lgCMN. Objective: Through comprehensive transcriptome analysis, this study aimed to elucidate the ongoing regulation and homeostasis in lgCMN and identify potential targets for treatment.

Biography

Feng Xie is a Associate professor in Plastic & Reconstructed Surgery department in Ninth Hospital affiliated by medical school of Shang Hai Jiao Tong University. He obtained the both his Doctor degree and PhD degree in Shang Hai JiaoTong Universityin 2006. He is engaged in treatment of Congenital giant naevus for more than 10 years. The department of Plastic & Reconstructive surgery of Ninth hospital is the most famous plastic center of China. It has 300 beds and more than 100 physicians in the department. Dr. Xie has engaged in Plastic surgery for more than twenty years. He usually use tissue expander to treat giant naevus. However, there are some patients with huge naevus that can not be treated using tissue expander. To solve this problem Dr. Xie is engaged in the study to treat the congenital giant naevus with target drug or immunotherapy. He has published over 20 English papers in this field.