Demyelinating Disorders

The damage of the protective covering (myelin sheath) that surrounds nerve fibers in brain, optic nerves and spinal cord leads to development of demyelinating disorders. The damaged myelin sheath makes the nerve impulses slow or even stop, causing neurological problems. Demyelination causes neurological deficits, such as vision changes, weakness, altered sensation, and behavioral or cognitive problems. Demyelination can occur at any age.

Symptoms of demyelinating diseases include

  • Loss of vision
  • Numbness or tingling of  upper or lower limbs
  • Weakness of the arms or legs
  • Poor coordination/gait problem
  • Trouble walking
  • Difficulty in swallowing
  • Slurred speech
  • Deceased bowel or bladder control
  • Impaired memory
  • Mood or behavioral changes

Genetic mutations, infectious agents, autoimmune reactions, Vitamin B12 deficiency and other unknown factors results in dysmyelination.


  • Acute Disseminated Encephalomyelitis
  • Balo’s Disease
  • Charcot-Marie-Tooth Disease
  • Guillain-Barre Syndrome
  • HTLV-I Associated Myelopathy
  • Neuromyelitis Optica
  • Schilder’s Disease
  • Transverse Myelitis
  • Diagnosis and treatment

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