Neurodegenerative disease is the group of condition or disease which mainly affect the neurons of the brain. The neurons are the building block of the brain and spinal cords or nervous system. Neurons are irreplaceable as they cannot replicate or reproduce after suffering damage which eventually death of the neuron.
Neurodegeneration is a loss in the structure and function of neurons.
Aging is the main cause of neurodegenerative disease. Neurodegenerative disease progress with age as the neurons become less functional. Oxidative stress, mitochondrial DNA mutation, and other factors lead a human body to age. Genetics, protein folding, DNA damage, mitochondrial dysfunction, programmed cell death, protein degradation pathways and other leads to the mechanism of neurodegenerative diseases. The cure of neurodegenerative disease is not yet discovered as causes of most of the cases are still a mystery.
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